Compositions having at least one flavonoid of natural or synthetic origin in association with melatonin to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumours are described. The compositions are in particular for the treatment of tumours resistant to the chemotherapeutic agents currently in use. The at least one flavonoid is selected from rutin, oxerutin, diosmin and hesperidin, preferably rutin.

Compositions having at least one flavonoid of natural or synthetic origin in association with melatonin to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumours are described. The compositions are in particular for the treatment of tumours resistant to the chemotherapeutic agents currently in use. The at least one flavonoid is selected from rutin, oxerutin, diosmin and hesperidin, preferably rutin.

Compositions having at least one flavonoid of natural or synthetic origin in association with melatonin to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumours are described. The compositions are in particular for the treatment of tumours resistant to the chemotherapeutic agents currently in use. The at least one flavonoid is selected from rutin, oxerutin, diosmin and hesperidin, preferably rutin.

The present invention discloses a traditional Chinese medicine composition for treating diseases caused by human papillomavirus, a preparation method and use thereof. The traditional Chinese medicine composition comprises: 15-60 parts of Rhizoma Smilacis Glabrae, 7.5-30 parts of Sophora Flavescens, 10-40 parts of Herba Hedyotidis Diffusae, 10-40 parts of Herba Taraxaci, 6-24 parts of Dysosma Versipellis, 7.5-30 parts of Nidus Vespae, 10-40 parts of Cortex Phellodendri, 2.5-10 parts of Fructus Bruceae, 7.5-30 parts of Fructus Cnidii, 3-12 parts of Radix Glycyrrhizae, 7.5-30 parts of Flos Lonicerae, 7.5-30 parts of Folium Isatidis, 5-20 parts of Radix Semiaquilegiae, and 1000-2000 parts of 75% ethanol. The traditional Chinese medicine composition has good curative effect and good safety.

The present invention discloses a traditional Chinese medicine composition for treating diseases caused by human papillomavirus, a preparation method and use thereof. The traditional Chinese medicine composition comprises: 15-60 parts of Rhizoma Smilacis Glabrae, 7.5-30 parts of Sophora Flavescens, 10-40 parts of Herba Hedyotidis Diffusae, 10-40 parts of Herba Taraxaci, 6-24 parts of Dysosma Versipellis, 7.5-30 parts of Nidus Vespae, 10-40 parts of Cortex Phellodendri, 2.5-10 parts of Fructus Bruceae, 7.5-30 parts of Fructus Cnidii, 3-12 parts of Radix Glycyrrhizae, 7.5-30 parts of Flos Lonicerae, 7.5-30 parts of Folium Isatidis, 5-20 parts of Radix Semiaquilegiae, and 1000-2000 parts of 75% ethanol. The traditional Chinese medicine composition has good curative effect and good safety.

To provide an inhibitor of melanin decomposition, which inhibits decomposition of melanin in keratinocytes to accelerate accumulation of melanin in skin and hair. An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of a plant extract containing berberine or a salt thereof, berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof, as an active ingredient.

To provide an inhibitor of melanin decomposition, which inhibits decomposition of melanin in keratinocytes to accelerate accumulation of melanin in skin and hair. An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of a plant extract containing berberine or a salt thereof, berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof, as an active ingredient.

To provide an inhibitor of melanin decomposition, which inhibits decomposition of melanin in keratinocytes to accelerate accumulation of melanin in skin and hair. An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of a plant extract containing berberine or a salt thereof, berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof, as an active ingredient.

The present invention relates to a biologically active supplement formulated in an oral dosage form comprising nutraceutically effective amounts of an extract of Usnea barbata lichen, three-lobe beggarticks herb and common barberry berries and having an over-cumulative antibacterial, including bactericidal, action against the wide range of pathogens and conditional human pathogens, as well as over-cumulative antifungal action, including fungistatic and fungicidal actions. In addition, the supplement can comprise black elder berry extract, Baikal skullcap root extract, and fermented black garlic powder.

The biologically active supplement of the invention can be used for enhancement of the general non-specific resistance of the body and for prevention or adjuvant therapy of the wide range of bacterial and fungal infections.

The present invention relates to a biologically active supplement formulated in an oral dosage form comprising nutraceutically effective amounts of an extract of Usnea barbata lichen, three-lobe beggarticks herb and common barberry berries and having an over-cumulative antibacterial, including bactericidal, action against the wide range of pathogens and conditional human pathogens, as well as over-cumulative antifungal action, including fungistatic and fungicidal actions. In addition, the supplement can comprise black elder berry extract, Baikal skullcap root extract, and fermented black garlic powder.

The biologically active supplement of the invention can be used for enhancement of the general non-specific resistance of the body and for prevention or adjuvant therapy of the wide range of bacterial and fungal infections.