The present invention relates to a bioactive agent capable of increasing the intracellular concentration and/or activity of Hsp70 for use in the treatment of a lysosomal storage disease which arise from a defect in an enzyme whose activity is not directly associated with the presence of lysosomal BMP as a co-factor; such as glycogen storage diseases, gangliosidoses, neuronal ceroid lipofuscinoses, cerebrotendinous cholesterosis, Wolman's disease, cholesteryl ester storage disease, disorders of glycosaminoglycan metabolism, mucopolysaccharidoses, disorders of glycoprotein metabolism, mucolipidoses, aspartylglucosaminuria, fucosidosis, mannosidoses, and sialidosis type II.

In connection with an access of content from a cache, a snoop request can be sent to one or more remote cache devices to determine if any other cache has a copy of the content. A link between the cache and the remote cache devices can include a snoop bypass device. The snoop bypass device can monitor content cached by the one or more remote devices on a cache line or coarser granularity. The snoop bypass device can respond to the snoop request with a negative indication based on a coarser granularity tracking of content of the one or more remote cache devices.

In connection with an access of content from a cache, a snoop request can be sent to one or more remote cache devices to determine if any other cache has a copy of the content. A link between the cache and the remote cache devices can include a snoop bypass device. The snoop bypass device can monitor content cached by the one or more remote devices on a cache line or coarser granularity. The snoop bypass device can respond to the snoop request with a negative indication based on a coarser granularity tracking of content of the one or more remote cache devices.

A graphics processing system is disclosed having a cache system (24) arranged between memory (23) and the graphics processor (20), the cache system comprising a first cache (53) for transferring data to and from the graphics processor (20) and a second cache (54) arranged and configured to transfer data between the first cache (53) and memory (23). When data is to be written from the first cache (53) to memory (23), a cache controller (55) determines a data type of the data and, in dependence on the data type, either causes the data to be written into the second cache (54) without writing the data to memory (23), or causes the data to be written to memory (23) without storing the data in the second cache (54). In embodiments the second cache (54) is write-only allocated.

A graphics processing system is disclosed having a cache system (24) arranged between memory (23) and the graphics processor (20), the cache system comprising a first cache (53) for transferring data to and from the graphics processor (20) and a second cache (54) arranged and configured to transfer data between the first cache (53) and memory (23). When data is to be written from the first cache (53) to memory (23), a cache controller (55) determines a data type of the data and, in dependence on the data type, either causes the data to be written into the second cache (54) without writing the data to memory (23), or causes the data to be written to memory (23) without storing the data in the second cache (54). In embodiments the second cache (54) is write-only allocated.

Operating system deactivation of write protection for a storage block is provided absent quiescing of processors in a multi-processor computing environment. The process includes receiving an address translation protection exception interrupt resulting from an attempted write access by a processor to a storage block, and determining by the operating system whether write protection for the storage block is active. Based on write protection for the storage block not being active, the operating system issues an instruction to clear or modify translation lookaside buffer entries of the processor associated with the storage block, absent waiting for an action by another processor of multiple processors of the computing environment, to facilitate write access to the storage block proceeding at the processor.

A gateway for interfacing a host with a subsystem for acting as a work accelerator to the host. The gateway enables the transfer of batches of data to the subsystem at precompiled data exchange synchronisation points. The gateway acts to route data between accelerators which are connected in a scaled system of multiple gateways and accelerators using a global address space set up at compile time of an application to run on the computer system.

An apparatus includes a CPU core, a first cache subsystem coupled to the CPU core, and a second memory coupled to the cache subsystem. The first cache subsystem includes a configuration register, a first memory, and a controller. The controller is configured to: receive a request directed to an address in the second memory and, in response to the configuration register having a first value, operate in a non-caching mode. In the non-caching mode, the controller is configured to provide the request to the second memory without caching data returned by the request in the first memory. In response to the configuration register having a second value, the controller is configured to operate in a caching mode. In the caching mode the controller is configured to provide the request to the second memory and cache data returned by the request in the first memory.

An apparatus includes a CPU core, a first cache subsystem coupled to the CPU core, and a second memory coupled to the cache subsystem. The first cache subsystem includes a configuration register, a first memory, and a controller. The controller is configured to: receive a request directed to an address in the second memory and, in response to the configuration register having a first value, operate in a non-caching mode. In the non-caching mode, the controller is configured to provide the request to the second memory without caching data returned by the request in the first memory. In response to the configuration register having a second value, the controller is configured to operate in a caching mode. In the caching mode the controller is configured to provide the request to the second memory and cache data returned by the request in the first memory.

An integrated circuit (IC) including a plurality of processor cores, a plurality of graphics processing units, a plurality of peripheral circuits, and a plurality of memory controllers is configured to support scaling of the system using a unified memory architecture. For example, the IC may include an interconnect fabric configured to provide communication between the one or more memory controller circuits and the processor cores, graphics processing units, and peripheral devices; and an off-chip interconnect coupled to the interconnect fabric and configured to couple the interconnect fabric to a corresponding interconnect fabric on another instance of the integrated circuit, wherein the interconnect fabric and the off-chip interconnect provide an interface that transparently connects the one or more memory controller circuits, the processor cores, graphics processing units, and peripheral devices in either a single instance of the integrated circuit or two or more instances of the integrated circuit.