Patent classifications
A61K36/47
DRUG DELIVERY SYSTEM BASED ON CALCIUM PHOSPHATE NANOPARTICLES FUNCTIONALIZED WITH BIOACTIVE COMPOUNDS FROM EUPHORBIA EXTRACT AND THE USES THEREOF
- Francisco BERMUDEZ PEREZ ,
- José Carlos PRADOS SALAZAR ,
- Consolacion MELGUIZO ALONSO ,
- Jusus M PORRES FOULQUIE ,
- Cristina MESAS HERNANDEZ ,
- Rosario MARTINEZ MARTINEZ ,
- Milagros GALISTEO MOYA ,
- Raul ORTIZ QUESADA ,
- Laura CABEZA MONTILLA ,
- Maria LOPEZ-JURADO ROMERO DE LA C ,
- Antonio Femando MURILLO CANCHO ,
- Jose Manuel DELGADO LOPEZ ,
- Victor GARCES ROBLES ,
- Gloria Belen RAMIREZ RODRIGUEZ
The present invention relates to a composition comprising the bioactive molecules esculetin and euphorbetin, which present antitumor activity, so it may be used for the treatment and/or prevention of cancer, especially for colorectal, pancreatic and glioblastoma. Furthermore, it relates to a drug delivery system composed of nanoparticles of calcium phosphate functionalized with said bioactive molecules, preferably obtained from a Euphorbia extract. The invention also refers to the obtaining of an ethanolic extract of plant origin from defatted flour of mature seed of Euphorbia.
DRUG DELIVERY SYSTEM BASED ON CALCIUM PHOSPHATE NANOPARTICLES FUNCTIONALIZED WITH BIOACTIVE COMPOUNDS FROM EUPHORBIA EXTRACT AND THE USES THEREOF
- Francisco BERMUDEZ PEREZ ,
- José Carlos PRADOS SALAZAR ,
- Consolacion MELGUIZO ALONSO ,
- Jusus M PORRES FOULQUIE ,
- Cristina MESAS HERNANDEZ ,
- Rosario MARTINEZ MARTINEZ ,
- Milagros GALISTEO MOYA ,
- Raul ORTIZ QUESADA ,
- Laura CABEZA MONTILLA ,
- Maria LOPEZ-JURADO ROMERO DE LA C ,
- Antonio Femando MURILLO CANCHO ,
- Jose Manuel DELGADO LOPEZ ,
- Victor GARCES ROBLES ,
- Gloria Belen RAMIREZ RODRIGUEZ
The present invention relates to a composition comprising the bioactive molecules esculetin and euphorbetin, which present antitumor activity, so it may be used for the treatment and/or prevention of cancer, especially for colorectal, pancreatic and glioblastoma. Furthermore, it relates to a drug delivery system composed of nanoparticles of calcium phosphate functionalized with said bioactive molecules, preferably obtained from a Euphorbia extract. The invention also refers to the obtaining of an ethanolic extract of plant origin from defatted flour of mature seed of Euphorbia.
HERBAL COMPOSITION FOR BREAST CANCER PREVENTION
A composition for use in protecting the breast tissue and significantly lowering the high risk for breast cancer development in women includes Ganoderma Lucidum, Quercetine, Embilica officinalis, Indole 3 carbinol, Camellia sinensis, Allium sativum, Iodine, and Selenium.
STEAM THERAPY EQUIPMENT FOR GOOD HEALTH AND WELLNESS
A steam therapy equipment including a vessel for heating a mixture of water and organic materials, a compressor to inject pressurized air into the vessel producing pressurized steam. The pressurized steam is conducted into the equipment via one or more valves. The therapy equipment is formed from at least one panel and may include a supporting frame. The therapy equipment includes a temperature sensor to measure the temperature inside the therapy equipment when pressurized steam is admitted via the valves. A patient enters the equipment and is exposed to the pressurized steam, causing dilation of the skin pores of the patient, whereby toxins are removed from the patient. One or more applicators may conduct pressurized steam to specific portions of the body of the patient. The patient may be provided with a portion of the mixture to consume as part of the steam therapy treatment.
STEAM THERAPY EQUIPMENT FOR GOOD HEALTH AND WELLNESS
A steam therapy equipment including a vessel for heating a mixture of water and organic materials, a compressor to inject pressurized air into the vessel producing pressurized steam. The pressurized steam is conducted into the equipment via one or more valves. The therapy equipment is formed from at least one panel and may include a supporting frame. The therapy equipment includes a temperature sensor to measure the temperature inside the therapy equipment when pressurized steam is admitted via the valves. A patient enters the equipment and is exposed to the pressurized steam, causing dilation of the skin pores of the patient, whereby toxins are removed from the patient. One or more applicators may conduct pressurized steam to specific portions of the body of the patient. The patient may be provided with a portion of the mixture to consume as part of the steam therapy treatment.
Curcuma longa (turmeric) based herbal compound formulations as dietary supplements
Herbal compound formulations using herbs curcuma longa (turmeric), ocimum sanctum (holy basil) and emblica officinalis (amla) in their natural forms and a method of packaging the same for dietary supplement as tablets, wafers, capsules and as teabags where the packaging of individual dosages and the outer packaging may use visual display of color that represents the proportion and presence of different herbs in the herbal compound.
Curcuma longa (turmeric) based herbal compound formulations as dietary supplements
Herbal compound formulations using herbs curcuma longa (turmeric), ocimum sanctum (holy basil) and emblica officinalis (amla) in their natural forms and a method of packaging the same for dietary supplement as tablets, wafers, capsules and as teabags where the packaging of individual dosages and the outer packaging may use visual display of color that represents the proportion and presence of different herbs in the herbal compound.
COMPOSITIONS IN SUPPORT OF HEALTH AND MENTAL ACCUITY
A composition includes ashwagandha in a range of 5% to 20%; plant-based nitric oxide-inducing ingredients in a range of 0.5% to 10%; coffee fruit extract in a range of 0.5% to 10%; grape seed extract in a range of 1% to 10%; Cordyceps in a range of 5% to 20%; extended-release caffeine in a range of 0.5% to 10%; whole coffee fruit extract in a range of 1% to 10%; Schisandra extract in a range of 1% to 10%; L-theanine in a range of 1% to 10%; and beet juice in a range of 20% to 60%.
COMPOSITIONS IN SUPPORT OF HEALTH AND MENTAL ACCUITY
A composition includes ashwagandha in a range of 5% to 20%; plant-based nitric oxide-inducing ingredients in a range of 0.5% to 10%; coffee fruit extract in a range of 0.5% to 10%; grape seed extract in a range of 1% to 10%; Cordyceps in a range of 5% to 20%; extended-release caffeine in a range of 0.5% to 10%; whole coffee fruit extract in a range of 1% to 10%; Schisandra extract in a range of 1% to 10%; L-theanine in a range of 1% to 10%; and beet juice in a range of 20% to 60%.
METHODS AND COMPOSITIONS FOR TREATING CHEMOTHERAPY-INDUCED DIARRHEA
Presented herein are methods for treating diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.