Methods for preparing tannic acid-containing compositions (e.g., pharmaceutical compositions, nutraceutical compositions or medical food compositions), particularly those having enriched tannic acid populations with superior potency, purity and safety profile. Also provide herein are the tannic acid-containing compositions for use in inhibiting D-amino acid oxidase and/or for treating CNS disorder and obesity disorders including diabetes, hyperglycemia, hyperlipidemia or hypercholesterolemia.

A pharmaceutical composition comprising a tannin selected from 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-?-D-glucose, 3-O-digalloyl-1,2,4,6-tetra-O-galloyl-?-D-glucose, 6-O-digalloyl-1,2,3,4-tetra-O-galloyl-?-D-glucose, 2,6-bis-O-digalloyl-1,3-di-O-galloyl-?-D-glucose, and 6-O-trigalloyl-1,2,3-tri-O-galloyl-?-D-glucose. The tannin may be derived from Quercus infectoria. The pharmaceutical composition is used in a method of treating cancer, particularly oral cancer.

A pharmaceutical composition comprising a tannin selected from 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-?-D-glucose, 3-O-digalloyl-1,2,4,6-tetra-O-galloyl-?-D-glucose, 6-O-digalloyl-1,2,3,4-tetra-O-galloyl-?-D-glucose, 2,6-bis-O-digalloyl-1,3-di-O-galloyl-?-D-glucose, and 6-O-trigalloyl-1,2,3-tri-O-galloyl-?-D-glucose. The tannin may be derived from Quercus infectoria. The pharmaceutical composition is used in a method of treating cancer, particularly oral cancer.

A flavored or unflavored pet treat-item using hemp based products and byproducts constructed to be eaten by a pet as a treat in one to two days. The outer shell of the treat-item is patterned after natural tree bark such as Pine, Cypress, Redwood and Oak. The treat-item contains supplements that provide pets the beneficial support from cannabanoids such as CBAs, CBDs and CBNs for which may help treatment of ailments such as arthritis, hip pain, tumors, leukemia, cancers, organ tissue repair and neurological regeneration; as well as, fiber support for teeth and digestive system health. A viscous version of the product in the form of baby food may be produced for tube feeding pets with more advanced debilitations.

A flavored or unflavored pet treat-item using hemp based products and byproducts constructed to be eaten by a pet as a treat in one to two days. The outer shell of the treat-item is patterned after natural tree bark such as Pine, Cypress, Redwood and Oak. The treat-item contains supplements that provide pets the beneficial support from cannabanoids such as CBAs, CBDs and CBNs for which may help treatment of ailments such as arthritis, hip pain, tumors, leukemia, cancers, organ tissue repair and neurological regeneration; as well as, fiber support for teeth and digestive system health. A viscous version of the product in the form of baby food may be produced for tube feeding pets with more advanced debilitations.

The present invention provides a composition for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, an antihistamine composition, and an anti-inflammatory composition. The present invention provides a method for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, a method for inhibiting the release of histamine, and a method for preventing, improving, or treating inflammatory disorders. The composition according to the present invention has excellent inhibitory activities for IL-4 generation, the degranulation of mast cells, COX-2, 15-NOX, and the passing of allergens from through an intestinal epithelial cell layer, or an excellent Treg cell inducing activity. Further, the present invention provides a detailed mechanism of action of a natural substance and a food-drived antiallergenic substance, and provides stability, a reduction in production costs, and improved convenience of use by using a natural substance as a material.

The present invention provides a composition for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, an antihistamine composition, and an anti-inflammatory composition. The present invention provides a method for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, a method for inhibiting the release of histamine, and a method for preventing, improving, or treating inflammatory disorders. The composition according to the present invention has excellent inhibitory activities for IL-4 generation, the degranulation of mast cells, COX-2, 15-NOX, and the passing of allergens from through an intestinal epithelial cell layer, or an excellent Treg cell inducing activity. Further, the present invention provides a detailed mechanism of action of a natural substance and a food-drived antiallergenic substance, and provides stability, a reduction in production costs, and improved convenience of use by using a natural substance as a material.

The present invention provides a composition for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, an antihistamine composition, and an anti-inflammatory composition. The present invention provides a method for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, a method for inhibiting the release of histamine, and a method for preventing, improving, or treating inflammatory disorders. The composition according to the present invention has excellent inhibitory activities for IL-4 generation, the degranulation of mast cells, COX-2, 15-NOX, and the passing of allergens from through an intestinal epithelial cell layer, or an excellent Treg cell inducing activity. Further, the present invention provides a detailed mechanism of action of a natural substance and a food-drived antiallergenic substance, and provides stability, a reduction in production costs, and improved convenience of use by using a natural substance as a material.

Methods for preparing tannic acid-containing compositions (e.g., pharmaceutical compositions, nutraceutical compositions or medical food compositions), particularly those having enriched tannic acid populations with superior potency, purity and safety profile. Also provide herein are the tannic acid-containing compositions for use in inhibiting D-amino acid oxidase and/or for treating CNS disorder and obesity disorders including diabetes, hyperglycemia, hyperlipidemia or hypercholesterolemia.

Extracts of the leaves, bark, and seeds/fruits of Castanea sativa Mill., syn. Castanea vesca Gaertn., and extracts of aerial parts of Cistus x incanus L., possess antibacterial activity against Helicobacter pylori and anti-inflammatory activity at the gastric level, and are therefore useful to relieve gastrointestinal inflammations, in particular those caused by Helicobacter pylori.