A pharmaceutical composition for treating oral ulcer, a preparation method and an application thereof are provided, which belong to the technical field of pharmaceutical compositions. The pharmaceutical composition includes the following raw materials: 20-50 parts of Sanhuang mixture, 15-20 parts of lotus root powder, 30-50 parts of Galla chinensis, 10-20 parts of Lonicera japonica Thunb., 10-20 parts of vanilla bean, 10-20 parts of propolis, 5-8 parts of oak bark, 5-10 parts of tea, 3-5 parts of Asarum, 1-2 parts of Atractylodes macrocephala and 5-30 parts of chlorhexidine acetate. The pharmaceutical composition for treating oral ulcer has the efficacies of clearing away heat, detoxifying removing blood stasis and reducing swelling, promoting granulation and relieving pain, inhibiting bacteria and killing bacteria, and has the advantages of quick response, easy finding of raw materials and low cost, and has a good therapeutic effect for treating oral ulcer clinically.

A pharmaceutical composition for treating oral ulcer, a preparation method and an application thereof are provided, which belong to the technical field of pharmaceutical compositions. The pharmaceutical composition includes the following raw materials: 20-50 parts of Sanhuang mixture, 15-20 parts of lotus root powder, 30-50 parts of Galla chinensis, 10-20 parts of Lonicera japonica Thunb., 10-20 parts of vanilla bean, 10-20 parts of propolis, 5-8 parts of oak bark, 5-10 parts of tea, 3-5 parts of Asarum, 1-2 parts of Atractylodes macrocephala and 5-30 parts of chlorhexidine acetate. The pharmaceutical composition for treating oral ulcer has the efficacies of clearing away heat, detoxifying removing blood stasis and reducing swelling, promoting granulation and relieving pain, inhibiting bacteria and killing bacteria, and has the advantages of quick response, easy finding of raw materials and low cost, and has a good therapeutic effect for treating oral ulcer clinically.

A pharmaceutical composition for treating oral ulcer, a preparation method and an application thereof are provided, which belong to the technical field of pharmaceutical compositions. The pharmaceutical composition includes the following raw materials: 20-50 parts of Sanhuang mixture, 15-20 parts of lotus root powder, 30-50 parts of Galla chinensis, 10-20 parts of Lonicera japonica Thunb., 10-20 parts of vanilla bean, 10-20 parts of propolis, 5-8 parts of oak bark, 5-10 parts of tea, 3-5 parts of Asarum, 1-2 parts of Atractylodes macrocephala and 5-30 parts of chlorhexidine acetate. The pharmaceutical composition for treating oral ulcer has the efficacies of clearing away heat, detoxifying removing blood stasis and reducing swelling, promoting granulation and relieving pain, inhibiting bacteria and killing bacteria, and has the advantages of quick response, easy finding of raw materials and low cost, and has a good therapeutic effect for treating oral ulcer clinically.

A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.

A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.

Managing and treating elevated OS biomarkers in mammals such as companion animals with at least one of the supplements alpha-lipoic acid, carnitine, co-enzyme Q-10, ginger, green tea, licorice, milk thistle, garlic, honey. resveratrol, soybeans, tomatoes, turmeric, vitamin D, vitamin E, or selenium. Other compounds are Zinc, Vitamin E, Vitamin C, Quercetin, L-glutamine and Robuvit. Diagnosing an oxidative stress (OS) in a mammal detects an OS biomarker, selectively isoprostane and other antioxidant biomarkers such as HODE, microRNAs, TAC, GSH, MDA, and TNF-alpha. The sample can be saliva.

Managing and treating elevated OS biomarkers in mammals such as companion animals with at least one of the supplements alpha-lipoic acid, carnitine, co-enzyme Q-10, ginger, green tea, licorice, milk thistle, garlic, honey. resveratrol, soybeans, tomatoes, turmeric, vitamin D, vitamin E, or selenium. Other compounds are Zinc, Vitamin E, Vitamin C, Quercetin, L-glutamine and Robuvit. Diagnosing an oxidative stress (OS) in a mammal detects an OS biomarker, selectively isoprostane and other antioxidant biomarkers such as HODE, microRNAs, TAC, GSH, MDA, and TNF-alpha. The sample can be saliva.

Managing and treating elevated OS biomarkers in mammals such as companion animals with at least one of the supplements alpha-lipoic acid, carnitine, co-enzyme Q-10, ginger, green tea, licorice, milk thistle, garlic, honey. resveratrol, soybeans, tomatoes, turmeric, vitamin D, vitamin E, or selenium. Other compounds are Zinc, Vitamin E, Vitamin C, Quercetin, L-glutamine and Robuvit. Diagnosing an oxidative stress (OS) in a mammal detects an OS biomarker, selectively isoprostane and other antioxidant biomarkers such as HODE, microRNAs, TAC, GSH, MDA, and TNF-alpha. The sample can be saliva.

An object of the present invention is to provide a senescence retarding agent that delays the onset of senescence symptoms and extends longevity, and is superior in safety. The senescence retarding agent of the present invention that achieves the object is characterized by containing a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following: (a) a koji mold-fermented product of one or more kinds of beans and/or cereals selected from the group consisting of barley, black soybean, red rice, black rice, adzuki bean, adlay, Japanese millet, foxtail millet, and millet; (b) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of fruits selected from the group consisting of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (Japanese persimmon), papaya, nashi (Japanese pear), watermelon, ume (Japanese apricot), fig, karin (Chinese quince), pumpkin, kumquat, yuzu (Chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (Japanese plum); (c) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of root crops and/or potatoes selected from the group consisting of murasaki-imo (purple sweet potato), kikuimo (Jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (Japanese yam), daikon (Japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and turmeric; (d) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of flowers and/or leaf vegetables selected from the group consisting of cabbage, shiso (perilla), mulberry leaves, dokudami (Korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion; (e) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seaweeds selected from the group consisting of kombu (sea tangle), wakame (Undaria pinnatifida), and mozuku (Nemacystus decipiens); (f) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seeds selected from the group consisting of black sesame seeds, walnuts, and ginkgo nuts; and (g) a yeast- and/or lactic acid bacterium-fermented product of one or two kinds of mushrooms selected from the group consisting of maitake (Grifola frondosa) and shiitake (Lentinus edodes).

An object of the present invention is to provide a senescence retarding agent that delays the onset of senescence symptoms and extends longevity, and is superior in safety. The senescence retarding agent of the present invention that achieves the object is characterized by containing a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following: (a) a koji mold-fermented product of one or more kinds of beans and/or cereals selected from the group consisting of barley, black soybean, red rice, black rice, adzuki bean, adlay, Japanese millet, foxtail millet, and millet; (b) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of fruits selected from the group consisting of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (Japanese persimmon), papaya, nashi (Japanese pear), watermelon, ume (Japanese apricot), fig, karin (Chinese quince), pumpkin, kumquat, yuzu (Chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (Japanese plum); (c) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of root crops and/or potatoes selected from the group consisting of murasaki-imo (purple sweet potato), kikuimo (Jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (Japanese yam), daikon (Japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and turmeric; (d) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of flowers and/or leaf vegetables selected from the group consisting of cabbage, shiso (perilla), mulberry leaves, dokudami (Korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion; (e) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seaweeds selected from the group consisting of kombu (sea tangle), wakame (Undaria pinnatifida), and mozuku (Nemacystus decipiens); (f) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seeds selected from the group consisting of black sesame seeds, walnuts, and ginkgo nuts; and (g) a yeast- and/or lactic acid bacterium-fermented product of one or two kinds of mushrooms selected from the group consisting of maitake (Grifola frondosa) and shiitake (Lentinus edodes).