A pharmaceutical product of the present invention contains plant parts obtained from the neem tree Azadirachta indica or active ingredients derived from such plant parts for use in treating, preventing and/or alleviating symptoms of restless legs syndrome.

The present invention relates to the novel formulation for sustained or delayed release of rohitukine-rich Dysoxylum binectariferum extract/fraction and a process for preparing the same wherein the extract is wet-granulated using excipients i.e. biodegradable polymers and/or non-biodegradable polymers alone or in combination, and the said granules are either filled into a capsule or compressed into a tablet. The said formulation comprising a granulated extract/fraction of rohitukine-rich Dysoxylum binectariferum with polymers has resulted in a sustained release of the extract or fraction over a period of 16-24 hrs. The said formulations are useful in the treatment of inflammatory diseases.

The present invention relates to the novel formulation for sustained or delayed release of rohitukine-rich Dysoxylum binectariferum extract/fraction and a process for preparing the same wherein the extract is wet-granulated using excipients i.e. biodegradable polymers and/or non-biodegradable polymers alone or in combination, and the said granules are either filled into a capsule or compressed into a tablet. The said formulation comprising a granulated extract/fraction of rohitukine-rich Dysoxylum binectariferum with polymers has resulted in a sustained release of the extract or fraction over a period of 16-24 hrs. The said formulations are useful in the treatment of inflammatory diseases.

A composition for treating skin disorders including a mixture of herbal extracts of Azadirachta indica, Acacia catechu, Hemidesmus indicus, Phyllanthus emblica, Terminalia bellirica, Terminalia chebula and optionally Tinospora cordifolia and use thereof. A method for treating skin disorders using the composition is also disclosed.

A composition for treating skin disorders including a mixture of herbal extracts of Azadirachta indica, Acacia catechu, Hemidesmus indicus, Phyllanthus emblica, Terminalia bellirica, Terminalia chebula and optionally Tinospora cordifolia and use thereof. A method for treating skin disorders using the composition is also disclosed.

Process for producing water soluble Azadirachtin containing powder formulation from neem seed kernel with the help of native and external inclusion complex. The process comprises expelling a large proportion of oil from neem seed kernels (NSK) by cold pressing, extracting the so called de-oiled neem seed cake with water to form an aqueous solution in which the azadirachtin is complexed with water soluble polysaccharides and proteins. The enrichment of azadiractin in aqueous solution is achieved by addition of azadiractin containing inclusion complex and spray drying. This helps in retaining all naturally occurring limonoids of neem seed kernel along with native encapsulating agents such as polysaccharide-protein matrix and also achieve water soluble powder with higher amounts of azadirachtin (>6000-60,000 ppm) in it.

Process for producing water soluble Azadirachtin containing powder formulation from neem seed kernel with the help of native and external inclusion complex. The process comprises expelling a large proportion of oil from neem seed kernels (NSK) by cold pressing, extracting the so called de-oiled neem seed cake with water to form an aqueous solution in which the azadirachtin is complexed with water soluble polysaccharides and proteins. The enrichment of azadiractin in aqueous solution is achieved by addition of azadiractin containing inclusion complex and spray drying. This helps in retaining all naturally occurring limonoids of neem seed kernel along with native encapsulating agents such as polysaccharide-protein matrix and also achieve water soluble powder with higher amounts of azadirachtin (>6000-60,000 ppm) in it.

In some aspects, the techniques described herein relate to a topical dermatologic acne treatment method using a cream. The treatment method uses two steps, first providing a bactericidal component and second providing a skin revitalizing complex. The bactericidal component clears the acne causing bacteria. The subsequent skin revitalizing complex revitalizes and conditions the skin and aids in return of natural skin flora and microbiome to prevent subsequent outbreaks. The skin revitalizing complex can include a variety of components such as: niacinamide, retinol, bakuchiol, green coffee bean extract, green tea extract, epilobium fleischeri extract, citric acid, dimethicone, and pentaerythrityl tetracaprylate. The skin revitalizing complex restores natural elasticity and oil production of the skin, decrease sebum production, and provide necessary conditioning of the skin to provide for the natural skin flora and microbiome to repopulate and flourish on a surface of the skin.

In some aspects, the techniques described herein relate to a topical dermatologic acne treatment method using a cream. The treatment method uses two steps, first providing a bactericidal component and second providing a skin revitalizing complex. The bactericidal component clears the acne causing bacteria. The subsequent skin revitalizing complex revitalizes and conditions the skin and aids in return of natural skin flora and microbiome to prevent subsequent outbreaks. The skin revitalizing complex can include a variety of components such as: niacinamide, retinol, bakuchiol, green coffee bean extract, green tea extract, epilobium fleischeri extract, citric acid, dimethicone, and pentaerythrityl tetracaprylate. The skin revitalizing complex restores natural elasticity and oil production of the skin, decrease sebum production, and provide necessary conditioning of the skin to provide for the natural skin flora and microbiome to repopulate and flourish on a surface of the skin.

The present invention relates to the use of a Lansium domesticum leaf extract for decreasing the pigmentation of the skin and/or of the skin appendages, and/or decreasing the pigment spots on the skin.

The extract according to the invention is present in a cosmetic composition comprising at least one cosmetically acceptable excipient.

Another subject of the invention relates to a cosmetic care process comprising the topical application of the extract according to the invention or of the cosmetic composition comprising same, for decreasing the pigmentation of the skin and/or of the skin appendages, and/or decreasing the pigment spots on the skin.

Yet another subject of the invention relates to the L. domesticum leaf extract for the pharmaceutical, preferentially dermatological, use thereof in the treatment of pathological conditions involving a pigment dysregulation.