A pharmaceutical product of the present invention contains plant parts obtained from the neem tree Azadirachta indica or active ingredients derived from such plant parts for use in treating, preventing and/or alleviating symptoms of restless legs syndrome.

A transdermal formulation which can be applied to the skin, body, face using a combination of glutathione, in the presence of a wide range of active components while increasing permeation of active antioxidant agents. A therapeutically effective amount creates in the patient (i) regulation of sleep, (ii) increased energy during awake periods, (iii) improved concentration during awake periods, (iv) reduction of facial wrinkles, and (v) reduction of joint and muscular pain with increases by at least 10 percent of the ability of skin to retain moisture and totally absorb the glutathione without requiring injection or oral supplementation of the glutathione.

A transdermal formulation which can be applied to the skin, body, face using a combination of glutathione, in the presence of a wide range of active components while increasing permeation of active antioxidant agents. A therapeutically effective amount creates in the patient (i) regulation of sleep, (ii) increased energy during awake periods, (iii) improved concentration during awake periods, (iv) reduction of facial wrinkles, and (v) reduction of joint and muscular pain with increases by at least 10 percent of the ability of skin to retain moisture and totally absorb the glutathione without requiring injection or oral supplementation of the glutathione.

A method to treat the skin condition vitiligo is described in this invention. The method comprises topical application of a composition containing cannabinoids, in particular cannabidiol and cannabigerol, at a concentration of 3%-20% by weight of the composition onto the affected skin area of a subject in need thereof. Application may be twice (2) daily for about six (6) weeks. Cannabidiol and cannabigerol may be sourced naturally or synthetically.

A method to treat the skin condition vitiligo is described in this invention. The method comprises topical application of a composition containing cannabinoids, in particular cannabidiol and cannabigerol, at a concentration of 3%-20% by weight of the composition onto the affected skin area of a subject in need thereof. Application may be twice (2) daily for about six (6) weeks. Cannabidiol and cannabigerol may be sourced naturally or synthetically.

Provided is a material useful for preventing or ameliorating uneven skin tone, prevention or amelioration of uneven skin tone by enhancing autophagic activity, and a method for evaluating or selecting an agent for preventing or ameliorating uneven skin tone using an autophagic activity-enhancing action as an indicator.

Provided is a material useful for preventing or ameliorating uneven skin tone, prevention or amelioration of uneven skin tone by enhancing autophagic activity, and a method for evaluating or selecting an agent for preventing or ameliorating uneven skin tone using an autophagic activity-enhancing action as an indicator.

A composition for the treatment of Demodex blepharitis containing tea tree oil and/or Neem oil and coconut oil in glycerol or in water or in a mixture of glycerol and water. The composition may further contain aloe barbadensis gel, sodium lauryl sulfate, cocoamidopropyl betaine, lauroyl glucoside, or DMDM hydantoin, or a combination thereof, in glycerol or in water or in a mixture of glycerol and water. The composition is used to treat Demodex blepharitis by applying the composition to the eyelid margin and eyelashes and scrubbing the eyelid margin, eyelashes, and eyelash roots with the composition using any suitable cloth, wipe, sponge, brush, or cotton tipped applicator.

A composition for the treatment of Demodex blepharitis containing tea tree oil and/or Neem oil and coconut oil in glycerol or in water or in a mixture of glycerol and water. The composition may further contain aloe barbadensis gel, sodium lauryl sulfate, cocoamidopropyl betaine, lauroyl glucoside, or DMDM hydantoin, or a combination thereof, in glycerol or in water or in a mixture of glycerol and water. The composition is used to treat Demodex blepharitis by applying the composition to the eyelid margin and eyelashes and scrubbing the eyelid margin, eyelashes, and eyelash roots with the composition using any suitable cloth, wipe, sponge, brush, or cotton tipped applicator.

A composition for the treatment of Demodex blepharitis containing tea tree oil and/or Neem oil and coconut oil in glycerol or in water or in a mixture of glycerol and water. The composition may further contain aloe barbadensis gel, sodium lauryl sulfate, cocoamidopropyl betaine, lauroyl glucoside, or DMDM hydantoin, or a combination thereof, in glycerol or in water or in a mixture of glycerol and water. The composition is used to treat Demodex blepharitis by applying the composition to the eyelid margin and eyelashes and scrubbing the eyelid margin, eyelashes, and eyelash roots with the composition using any suitable cloth, wipe, sponge, brush, or cotton tipped applicator.