Various formulations of an alkaloid-containing topical analgesic involve extracting alkaloids from herbal material, infusing a carrier oil, and applying secondary ingredients to improve the formulation's therapeutic efficacy. Suitable herbal sources include, but are not limited to, Mitragyna speciosa, Rauwolfia serpentina, Sceletium tortuosum, Harpagophytum procumbens, Picralima natilda, Sceletium tortuosum, Combretum quadrangulare, Corydalis yanhusuo, Lactuca virosa, and/or Magnolia officinalis. Preferably, alcohol extractions of pre-frozen herbal material were vacuum reduced and the resulting alkaloid extraction was infused into an oil and combined with secondary ingredients, such as alkaloid potentiators, dermal absorption enhancers, anti-inflammation agents, brightening agents, neuropathic pain relief agents, and spasm relief agents.

Various formulations of an alkaloid-containing topical analgesic involve extracting alkaloids from herbal material, infusing a carrier oil, and applying secondary ingredients to improve the formulation's therapeutic efficacy. Suitable herbal sources include, but are not limited to, Mitragyna speciosa, Rauwolfia serpentina, Sceletium tortuosum, Harpagophytum procumbens, Picralima natilda, Sceletium tortuosum, Combretum quadrangulare, Corydalis yanhusuo, Lactuca virosa, and/or Magnolia officinalis. Preferably, alcohol extractions of pre-frozen herbal material were vacuum reduced and the resulting alkaloid extraction was infused into an oil and combined with secondary ingredients, such as alkaloid potentiators, dermal absorption enhancers, anti-inflammation agents, brightening agents, neuropathic pain relief agents, and spasm relief agents.

The use of at least one flavonoid of natural or synthetic origin in association with cyclophosphamide and/or methotrexate to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumors is described, in particular in case of resistance to the chemotherapeutic agents currently in use. At least one flavonoid herein described is selected from the group comprising or, alternatively, consisting of rutin, oxerutin, diosmin, troxerutin and hesperidin.

The use of at least one flavonoid of natural or synthetic origin in association with cyclophosphamide and/or methotrexate to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumors is described, in particular in case of resistance to the chemotherapeutic agents currently in use. At least one flavonoid herein described is selected from the group comprising or, alternatively, consisting of rutin, oxerutin, diosmin, troxerutin and hesperidin.

The use of at least one flavonoid of natural or synthetic origin in association with cyclophosphamide and/or methotrexate to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumors is described, in particular in case of resistance to the chemotherapeutic agents currently in use. At least one flavonoid herein described is selected from the group comprising or, alternatively, consisting of rutin, oxerutin, diosmin, troxerutin and hesperidin.

Improved and safer products for preventing or alleviating coccidiosis, especially those that do not trigger the development of resistance are provided. A feed additive composition for preventing poultry coccidiosis comprising sabadilla seed, defatted sabadilla extract and/or extraction residue of sabadilla seed, a feed comprising said feed additive composition, and a method for preventing poultry coccidiosis using sabadilla seed, defatted sabadilla extract and/or extraction residue of sabadilla seed.

Improved and safer products for preventing or alleviating coccidiosis, especially those that do not trigger the development of resistance are provided. A feed additive composition for preventing poultry coccidiosis comprising sabadilla seed, defatted sabadilla extract and/or extraction residue of sabadilla seed, a feed comprising said feed additive composition, and a method for preventing poultry coccidiosis using sabadilla seed, defatted sabadilla extract and/or extraction residue of sabadilla seed.

Compositions having at least one flavonoid of natural or synthetic origin in association with melatonin to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumours are described. The compositions are in particular for the treatment of tumours resistant to the chemotherapeutic agents currently in use. The at least one flavonoid is selected from rutin, oxerutin, diosmin and hesperidin, preferably rutin.

Compositions having at least one flavonoid of natural or synthetic origin in association with melatonin to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumours are described. The compositions are in particular for the treatment of tumours resistant to the chemotherapeutic agents currently in use. The at least one flavonoid is selected from rutin, oxerutin, diosmin and hesperidin, preferably rutin.

Compositions having at least one flavonoid of natural or synthetic origin in association with melatonin to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumours are described. The compositions are in particular for the treatment of tumours resistant to the chemotherapeutic agents currently in use. The at least one flavonoid is selected from rutin, oxerutin, diosmin and hesperidin, preferably rutin.