A61K36/67

Nanoemulsion Compositions Comprising Saponins for Increasing Bioavailability
20220054414 · 2022-02-24 · ·

Nanoemulsion compositions, and lipid nanoparticle compositions, comprising natural bioactive agents with natural surfactants, such as saponins from the plant Quillaja saponaria and/or phospholipids derived from lecithin. The nanoemulsions are able to increase the bioavailability of the bioactive materials from plant and other sources (e.g. CBD, nutraceuticals, and vitamins). In an embodiment, the composition further comprises Terpenes or Terpenoids, Piperine, and Chitosan. The nanoemulsions are water-soluble and possess a droplet size (e.g. about 43 to 50 nm), which is better or comparable to those made with synthetic surfactants. Furthermore, the nanoemulsions increase the absorption and bioavailability of the bioactive component while decreasing the pre-systemic elimination and first-pass effect of the liver. Methods of making the nanoemulsions comprise sonification: at an energy level of 1000 Ws/g; or without pressure at 2000-2500 Ws/g while recirculating; or applying high pressure (1.5-2.0 bar(g)) while circulating at 1500 Ws/g.

Nanoemulsion Compositions Comprising Saponins for Increasing Bioavailability
20220054414 · 2022-02-24 · ·

Nanoemulsion compositions, and lipid nanoparticle compositions, comprising natural bioactive agents with natural surfactants, such as saponins from the plant Quillaja saponaria and/or phospholipids derived from lecithin. The nanoemulsions are able to increase the bioavailability of the bioactive materials from plant and other sources (e.g. CBD, nutraceuticals, and vitamins). In an embodiment, the composition further comprises Terpenes or Terpenoids, Piperine, and Chitosan. The nanoemulsions are water-soluble and possess a droplet size (e.g. about 43 to 50 nm), which is better or comparable to those made with synthetic surfactants. Furthermore, the nanoemulsions increase the absorption and bioavailability of the bioactive component while decreasing the pre-systemic elimination and first-pass effect of the liver. Methods of making the nanoemulsions comprise sonification: at an energy level of 1000 Ws/g; or without pressure at 2000-2500 Ws/g while recirculating; or applying high pressure (1.5-2.0 bar(g)) while circulating at 1500 Ws/g.

Nanoemulsion Compositions Comprising Saponins for Increasing Bioavailability
20220054414 · 2022-02-24 · ·

Nanoemulsion compositions, and lipid nanoparticle compositions, comprising natural bioactive agents with natural surfactants, such as saponins from the plant Quillaja saponaria and/or phospholipids derived from lecithin. The nanoemulsions are able to increase the bioavailability of the bioactive materials from plant and other sources (e.g. CBD, nutraceuticals, and vitamins). In an embodiment, the composition further comprises Terpenes or Terpenoids, Piperine, and Chitosan. The nanoemulsions are water-soluble and possess a droplet size (e.g. about 43 to 50 nm), which is better or comparable to those made with synthetic surfactants. Furthermore, the nanoemulsions increase the absorption and bioavailability of the bioactive component while decreasing the pre-systemic elimination and first-pass effect of the liver. Methods of making the nanoemulsions comprise sonification: at an energy level of 1000 Ws/g; or without pressure at 2000-2500 Ws/g while recirculating; or applying high pressure (1.5-2.0 bar(g)) while circulating at 1500 Ws/g.

Compositions and methods affecting exercise performance

Described herein are compositions comprising activators of TRP and ASIC channels that may be useful to improve or preserve exercise performance and exercise recovery.

CAPSULE-CONTAINING POUCHED PRODUCT FOR ORAL USE
20220030928 · 2022-02-03 ·

A pouched product adapted for release of a releasable component therefrom is provided herein. The pouched product can include a water-permeable fabric pouch formed so as to define a cavity therein, and a composition contained within the cavity of the water-permeable fabric pouch, the composition including one or more releasable components that are released from the composition under mouth conditions and that are capable of movement through the water-permeable fabric pouch. The composition includes nicotine and at least one particulate non-tobacco material. The pouched product also includes at least one capsule contained within the cavity of the water-permeable fabric pouch, the capsule having a capsule wall surrounding an inner payload comprising at least one botanical.

CAPSULE-CONTAINING POUCHED PRODUCT FOR ORAL USE
20220030928 · 2022-02-03 ·

A pouched product adapted for release of a releasable component therefrom is provided herein. The pouched product can include a water-permeable fabric pouch formed so as to define a cavity therein, and a composition contained within the cavity of the water-permeable fabric pouch, the composition including one or more releasable components that are released from the composition under mouth conditions and that are capable of movement through the water-permeable fabric pouch. The composition includes nicotine and at least one particulate non-tobacco material. The pouched product also includes at least one capsule contained within the cavity of the water-permeable fabric pouch, the capsule having a capsule wall surrounding an inner payload comprising at least one botanical.

ANTI-ACHING SUPPLEMENT
20220031763 · 2022-02-03 ·

A composition of phyto-medicaments comprising essentially of Piper guineense, turmeric and Moringa oleifera for the treatment necessary to alleviate ailments associated therewith.

ANTI-ACHING SUPPLEMENT
20220031763 · 2022-02-03 ·

A composition of phyto-medicaments comprising essentially of Piper guineense, turmeric and Moringa oleifera for the treatment necessary to alleviate ailments associated therewith.

ANTI-ACHING SUPPLEMENT
20220031763 · 2022-02-03 ·

A composition of phyto-medicaments comprising essentially of Piper guineense, turmeric and Moringa oleifera for the treatment necessary to alleviate ailments associated therewith.

CAPSULE-CONTAINING POUCHED PRODUCT FOR ORAL USE
20220264931 · 2022-08-25 ·

A pouched product adapted for release of a releasable component therefrom is provided herein. The pouched product can include a water-permeable fabric pouch formed so as to define a cavity therein, and a composition contained within the cavity of the water-permeable fabric pouch, the composition including one or more releasable components that are released from the composition under mouth conditions and that are capable of movement through the water-permeable fabric pouch. The composition includes nicotine and at least one particulate non-tobacco material. The pouched product also includes at least one capsule contained within the cavity of the water-permeable fabric pouch, the capsule having a capsule wall surrounding an inner payload comprising at least one botanical.