The present disclosure relates to a computer implemented diffusion magnetic resonance method for determining a diffusion parameter for spin-labelled particles in a specimen. The method (100) comprises providing (110) a specimen and a magnetic resonance device arranged to measure magnetic resonance in said specimen; applying (120) at least one magnetic field gradient pulse sequence to said specimen, thereby spin-labelling a set of particles comprised in said specimen; obtaining (130) magnetic resonance measurement data corresponding to said at least one magnetic field gradient pulse sequence for said spin-labelled particles with said magnetic resonance device; determining (140) at least one diffusion parameter for said spin-labelled particles based on said obtained measurement data; wherein determining (140) said at least one diffusion parameter comprises forming for each diffusion parameter at least one Fourier transform representing said diffusion parameter based on said obtained measurement data; and wherein each magnetic field gradient pulse sequence comprises at least three gradient pulses wherein at least one gradient pulse is configured to introduce a phase shift in said spin-labelled particles based on their position in said specimen.

For a complex image to be complexly added, appropriate phase correction is executed by a simple method to prevent occurrence of an artifact in a signal region and to reduce noise in a background region. Two or more types of smoothing processing with different smoothing degrees are executed on a phase image of the complex image to obtain two or more types of smoothed phase images having different smoothing degrees. A weight for each of these smoothed phase images is calculated based on a signal value (SNR) of an intensity image, and addition is performed by a weight for each signal value to obtain a smoothed phase image for correction. After a phase of the complex image is corrected using the smoothed phase image, a phase-corrected complex image is complexly added. As a result, phase correction equivalent to phase correction in which a smoothing degree is weakened in the signal region and a smoothing degree is strengthened in the background region is realized.

A method for measuring a gradient field of a nuclear magnetic resonance (NMR) system based on a diffusion effect uses a non-uniform field magnet, an NMR spectrometer, a radio frequency (RF) power amplifier, an RF coil, and a standard quantitative phantom with known apparent diffusion coefficient (ADC) and time constant for decay of transverse magnetization after RF-pulse (T2). A plurality of sets of signals are acquired by an NMR sequence with different diffusion-sensitive gradient durations or different echo spacings and the magnitude of the gradient field is calculated by fitting based on the plurality of sets of signals. The method does not require an additional dedicated magnetic field detection device, has a short measurement time, is easy to use with the NMR system, and is convenient to complete gradient field measurement at the installation site, thereby improving the installation and service efficiency of the NMR system.

In a computer-implemented method of training a machine learning based processor, the processor can be trained to derive image data from signal data sets of multiple spin echo sequences. The trained processor can be configured to perform image processing for Magnetic Resonance Imaging (MRI) to derive the image data.

In a method for recording diffusion-weighted measurement data, using a MR system with diffusion weightings with two+ different b-values, diffusion directions and diffusion weightings with the associated b-values to be used for the desired recordings are loaded, a sequence of recordings of measurement data to be recorded consecutively are determined by sorting the diffusion directions and diffusion weightings to be recorded based on their associated b-value, such that the b-value of a recording of measurement data is less than the b-value of the immediately preceding recording of measurement data by no more than a predetermined threshold value, and the recordings are recorded based on the determined sequence. By arranging diffusion encodings for the desired recordings to be used consecutively, abrupt discontinuities in the b-values used chronologically are prevented, thereby eddy current effects from preceding recordings have time to abate in the case of recordings with small b-values.

A nuclear magnetic resonance (NMR) system-based substance measurement method, including: acquiring several echo signals of an NMR pulse sequence varying in echo spacing from a substance to be measured followed by processing to obtain several signals varying in transverse relaxation and diffusion attenuation; and fitting, in combination with the prior knowledge, the signals to obtain the diffusion coefficient, transverse relaxation time or/and content weight of individual components of the substance to be measured. This application further provides a substance measurement system including a console, a magnet module, and an NMR system.

According to one embodiment, a medical data processing apparatus includes processing circuitry. The processing circuitry acquires imaging data acquired by executing spoiled gradient echo imaging and coherent gradient echo imaging by using multiple flip angles. The processing circuitry generates a low-rank approximate image set, which is a set of low-rank approximated images from the imaging data. The processing circuitry reconstructs one or more parameter maps using the above low-rank approximate image set and a related to water exchange in a biological tissue, the multi-pool model including plural free waters and bound water that performs magnetization exchange with those free waters.

A universal, modular, temperature controlled MRI phantom for calibration and validation for anisotropic and isotropic imaging comprises an outer insulating shell configured to be received within an MRI chamber; an inner shell received within the outer insulating shell; a fluid conduits adjacent the inner shell for receiving temperature controlling fluid or gas cycling there-through; and a series of stacked layers of frames containing test points for the MRI phantom, each layer including at least one fiducial and including at least some anisotropic imaging test points in at least one frame and at least one isotropic imaging test point in at least one frame. The anisotropic imaging comprises hollow tubular textile fibers, wherein each hollow tubular fiber has an outer diameter of less than 50 microns and an inner diameter of less than 20 microns, wherein at least some hollow tubular fibers are filled with a fluid.

A method for accelerating diffusion magnetic resonance imaging (MRI) acquisition via slice interleaved diffusion encoding (SIDE) includes conducting a plurality of simultaneous multislice (SMS) excitations for each of a plurality of SIDE diffusion-weighted volumes to obtain SMS images of an MRI subject at different diffusion orientations, regrouping the images into slice groups with different orientations, generating a plurality of slice-undersampled diffusion weighted volumetric images of the subject, wherein each of the plurality of slice-undersampled diffusion weighted volumetric images is produced by cyclically interleaving the slice groups, such that each slice group is associated with a different diffusion wavevector, and reconstructing a full diffusion-weighted volumetric image of the subject by providing the plurality of slice-undersampled diffusion weighted volumetric images to a neural network trained to produce full diffusion-weighted volumetric versions of diffusion magnetic resonance images from undersampled versions of the diffusion magnetic resonance images.

In a method for acquiring measurement data using a magnetic resonance (MR) system having a gradient unit, frequency-dependent parameters characterizing the gradient unit of the MR system are accessed (e.g. loaded from a memory), a k-space trajectory of a RESOLVE (Readout Segmentation Of Long Variable Echo trains) sequence planned for a MR measurement is accessed, MR measurement data is acquired based on the planned k-space trajectory and reconstructing image data from the MR measurement data, and an electronic signal is provided that represents the reconstructed image data as an output of the MR system. The k-space trajectory may have a frequency component in at least one direction. The planned k-space trajectory may be corrected based on at least one frequency component of the planned k-space trajectory and the frequency-dependent parameters.