The ratio of arterial spin labeled (ASL) perfusion to diffusion weighted imaging (DWI) is generally homogeneous in the anoxic/hypoxic injury population. Conversely, the ratio is more heterogeneous in the non-anoxic/hypoxic population. By plotting these ratios in a graphical format in the form of an axial color map of the brain—referred to as a normalized diffusion to perfusion (NDP) ratio colormap—it may be determined whether a patient has suffered from an anoxic/hypoxic injury. Thus, the anoxic and non-anoxic injury patients will have, respectively, homogenous and heterogeneous color maps. Anoxic brain injury patients have a global homogeneously positive relationship between qualitative ASL perfusion and diffusion weighted signal such that areas of restricted diffusion show significantly increased ASL perfusion signal, which may be attributable to BBB integrity. The NDP ratio colormap provides an imaging biomarker to differentiate anoxic brain injury from normal controls and to potentially assess BBB integrity.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

A non-transitory storage medium stores instructions readable and executable by at least one electronic processor (20) to perform an imaging method (100). The method includes: obtaining multi-parametric magnetic resonance (MR) imaging data parameterized by a diffusion weighting or perfusion weighting parameter and a magnetization relaxation parameter for a region of interest (ROI) of a patient; determining volume fraction maps of the ROI for each of a plurality of tissue types from the multi-parametric MR imaging data; and controlling a display device (24) to display a tissue composition map comprising or generated from the determined volume fraction maps.

A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.

According to one embodiment, a medical image processing apparatus. The apparatus obtains MR dynamic images acquired by MR imaging on a subject, in which a contrast agent has been injected, in accordance with an examination-time imaging condition including magnetic field information, contrast agent information, and/or tissue information. The apparatus sets a standard imaging condition. The apparatus calculates a first index value indicating a temporal change of an MR signal value caused by the contrast agent, the index value being standardized by conversion from the examination-time imaging condition to the standard imaging condition based on the MR dynamic images, the examination-time imaging condition, and the standard imaging condition.

A magnetic resonance imaging (MRI) apparatus according to an exemplary embodiment includes a sequence controller and a data processor. The sequence controller executes a pulse sequence using a combination of multiple types of labeling methods to acquire magnetic resonance signals. The data processor generates multiple types of labeled images based on the magnetic resonance signals.

[Problem] The present invention provides analysis technology relating to video data of a fluorescent contrast agent shot by a microscope during an operation, and addresses the problem of providing a method and system allowing information such as BV, BF and MTT, and vascular wall thickness, to be estimated by fluorescent contrast agent analysis, by applying perfusion analysis methods, which allow estimation of information such as BV, BF and MTT, to fluorescent contrast agent analysis.

[Solution] The method for image processing of intravascular hemodynamics according to the present invention is characterized by shooting video using infrared light, wherein the object of shooting is a portion of a blood vessel injected with a standard amount of a fluorescent contrast agent; performing image analysis of a shape of a chronological change curve of intensity values which are image outputs from the video shooting; and calculating relative data for blood volume and blood flow based on results of the image analysis.

An MRI system and method for generating MR images is provided. An MR signals acquisition unit is configured to generate a main magnetic field, orienting the magnetization of blood within a subject, and first inversion/non-inversion RF pulses such that predetermined sequences of blood boli with inverted/non-inverted magnetization are generated. First inversion/non-inversion MR signals can be acquired, which are caused by the influence on the magnetization by the first inversion/non-inversion RF pulses. MR images may be generated by an image generation unit based on imaging MR signals, acquired after the sequences of inverted and non-inverted blood boli have been flowed from the first region to the part to be imaged, and the predetermined sequences. An evaluation unit is configured to evaluate the inverting of the magnetization in the first region based on the first inversion and/or non-inversion MR signals. In one embodiment, the labeling efficiency of a pseudo continuous arterial spin labeling (pCASL) MRI experiment is performed.

Methods and systems are provided for adaptive scan control. In one embodiment, a method includes processing acquired projection data of a monitoring area of a subject to measure a first contrast signal of a contrast agent administered to the subject via a first injection, initializing a contrast scan of the subject according to a fallback scan prescription, determining when each of a plurality of zones of the contrast scan are estimated to occur based on the contrast signal, generating a personalized scan prescription for the contrast scan based on when each of the plurality of zones are estimated to occur, and performing the contrast scan according to the personalized scan prescription after a second injection of the contrast agent.

Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The images are generated using acquired .sup.19F magnetic resonance image (MRI) signal data associated with the perfluorinated gas and oxygen mixture.