Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Systems and methods are described for computing a quantitative index that characterizes Alzheimer's disease (“AD”) risk events based on a temporally ordered sequence of biomarker events. In general, the systems and methods described here implement a modified event-based probabilistic (“EBP”) model to calculate the risk index from biomarker data.

An echo planar imaging technique in which a quadruple echo gradient and spin echo echo-planar imaging pulse sequence is utilized. The pulse train includes generation of two echo trains between an excitation pulse (90) and a refocusing pulse (180) to achieve two gradient echo images (also called T2*-weighted images); with one echo train directly after the 180 pulse, leading to asymmetric spin echo images (T2′-weighted images); and a last echo train afterward that generates spin echo images (T2-weighted). The technique has a number of advantages over existing techniques with regard to voxel size, mapping relative oxygen extraction, determining permeability, determining relative cerebral blood volume, vessel parameters (diameter, density, size, arterial/venous, etc.), stroke imaging, imaging perfusion, fMRI imaging, and additional benefits.

Devices and methods are provided for analyzing images from a magnetic resonance (MR) system. The device includes at least one hardware processor coupled with a storage system accessible to the at least one hardware processor. The device further includes a display in communication with the at least one hardware processor. The device receives a plurality of non-contrast MR images in a region of interest (ROI). The device obtains blood flow signals from the plurality of non-contrast MR images. The device identifies an abnormal segment by analyzing the blood flow signals. The device displays the non-contrast MR images by a highlighted segment in at least one of the non-contrast MR images to indicate the abnormal segment on the display.

Tracer kinetic models are utilized as temporal constraints for highly under-sampled reconstruction of DCE-MRI data. The method is flexible in handling any TK model, does not rely on tuning of regularization parameters, and in comparison to existing compressed sensing approaches, provides robust mapping of TK parameters at high under-sampling rates. In summary, the method greatly improves the robustness and ease-of-use while providing better quality of TK parameter maps than existing methods. In another embodiment, TK parameter maps are directly reconstructed from highly under-sampled DCE-MRI data. This method provides more accurate TK parameter values and higher under-sampling rates. It does not require tuning parameters and there are not additional intermediate steps. The proposed method greatly improves the robustness and ease-of-use while providing better quality of TK parameter maps than conventional indirect methods.

Some aspects of the present disclosure relate a method for magnetic resonance imaging, which can include acquiring, by applying an imaging pulse sequence, magnetic resonance data associated with a region of interest of a subject. The imaging pulse sequence can include a plurality of RF pulses configured to generate a desired image contrast, and an outer-volume suppression (OVS) module to attenuate the signal outside the region of interest. The method can further include reconstructing, from the acquired magnetic resonance data, a plurality of reduced field of view (rFOV) magnetic resonance images corresponding to the region of interest.

A magnetic resonance imaging apparatus according to an embodiment includes processing circuitry. The processing circuitry sets an imaging region and a labeling region based on at least a blood vessel structure, the imaging region being a region of a matrix of a plurality of divided voxels including different blood vessel regions, respectively, the labeling region being a region to which a labeling pulse for labeling blood flowing into the imaging region is applied. The processing circuitry acquires data of the imaging region by applying the labeling pulse to the labeling region by using an arterial spin labeling (ASL) method. The processing circuitry generates an image based on the data. The processing circuitry determines anomaly of the blood vessel regions by comparing signal values of the voxels included in the image.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

The invention relates to an imaging system for generating a series of images of a subject. Fluid boli are generated at a first location of the subject, wherein each fluid bolus comprises a sequence of sub-boli and wherein images of the series of images are acquired at a second location of the subject, after the fluid boli have been flowed to the second location. A sub-bolus length is determined based on at least one image of the already acquired images of the series of images, wherein a further fluid bolus comprising a sequence of sub-boli is generated at the first location, wherein at least one of the sub-boli has the determined sub-bolus length, and wherein a further image of the series of images is acquired at the second location of the subject, after the further fluid bolus has been flowed from the first location to the second location.

A magnetic resonance imaging apparatus according to an embodiment includes sequence control circuitry and processing circuitry. The sequence control circuitry executes a first pulse sequence and a second pulse sequence, the first pulse sequence including a first spoiler pulse serving as a dephasing gradient pulse of a first amount, the second pulse sequence including a second spoiler pulse serving as a dephasing gradient pulse of a second amount being different from the first amount or the second pulse sequence not including a spoiler pulse serving as a dephasing gradient pulse. The processing circuitry performs a subtraction operation between a first data obtained from the first pulse sequence and a second data obtained from the second pulse sequence, thereby generating an image.