The present invention relates to a pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases which include a flower extract of Daphne genkwa or fractions thereof as an active ingredient. The pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases are, not like extracts from stems and/or roots of Daphne genkwa, free from genotoxicity and have superior prophylactic or treatment effects against neurodegenerative diseases.

The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases, the composition containing a mixed herbal extract of Genkwae Flos, Clematidis Radix, and Gastrodiae Rhizoma. In addition the present invention relates to a food composition or feedstuff composition for preventing or improving neurodegenerative diseases, wherein the composition contains the herbal extract.

The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases, the composition containing a mixed herbal extract of Genkwae Flos, Clematidis Radix, and Gastrodiae Rhizoma. In addition the present invention relates to a food composition or feedstuff composition for preventing or improving neurodegenerative diseases, wherein the composition contains the herbal extract.

The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases, the composition containing a mixed herbal extract of Genkwae Flos, Clematidis Radix, and Gastrodiae Rhizoma. In addition the present invention relates to a food composition or feedstuff composition for preventing or improving neurodegenerative diseases, wherein the composition contains the herbal extract.

The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a diterpene, or a pharmaceutically acceptable salt thereof.

Specifically, the diterpene of the present invention can prevent or treat neurodegenerative diseases caused by inhibition of Nurr1 activity by activating Nurr1 and inhibiting the inflammatory response.

One aspect of the present disclosure relates to a functional food composition having a cranial nerve protective effect and a blood flow improvement effect and including antler, an Angelica gigasroot, a Cornus officinalis fruit, a Rehmannia glutinosa root, Lepidium meyenii root powder, a hawthorn fruit, an Astragalus membranaceus root, a cod seed, aloeo wood, a Paeonia lactiflora root, a Cnidium officinale root stem and a Citrus reticulata shell.

One aspect of the present disclosure relates to a functional food composition having a cranial nerve protective effect and a blood flow improvement effect and including antler, an Angelica gigasroot, a Cornus officinalis fruit, a Rehmannia glutinosa root, Lepidium meyenii root powder, a hawthorn fruit, an Astragalus membranaceus root, a cod seed, aloeo wood, a Paeonia lactiflora root, a Cnidium officinale root stem and a Citrus reticulata shell.

The present invention relates to a pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases which include a flower extract of Daphne genkwa or fractions thereof as an active ingredient. The pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases are, not like extracts from stems and/or roots of Daphne genkwa, free from genotoxicity and have superior prophylactic or treatment effects against neurodegenerative diseases.

The present invention relates to a pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases which include a flower extract of Daphne genkwa or fractions thereof as an active ingredient. The pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases are, not like extracts from stems and/or roots of Daphne genkwa, free from genotoxicity and have superior prophylactic or treatment effects against neurodegenerative diseases.

The present invention relates to a pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases which include a flower extract of Daphne genkwa or fractions thereof as an active ingredient. The pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases are, not like extracts from stems and/or roots of Daphne genkwa, free from genotoxicity and have superior prophylactic or treatment effects against neurodegenerative diseases.