A pharmaceutical composition containing dry powder of pine (Pinus) needles and dry peels and pits of grapes extract and pharmaceutically acceptable additive, dry extracts of ginger (Zingiber officinale), turmeric (Curcuma longa), white peony (Paeonia), Rhodiola Rosea (Rhodiola Rosea), apricot (Prunus) seed, oyster mushroom (Pleurotus ostreatus), green tea (Camellia sinensis), Ginkgo Biloba (Ginkgo biloba), white pepper, pomegranate (Punica granatum) pulp, medlar (Mespilus germanica), dry powder of pomegranate (Punica granatum) juice and folic acid, in the following ratio of the components in weight % (w %):

TABLE-US-00001 dry powder of pine needles and dry peels and pits of grapes extract and pharmaceutically acceptable additive 6-24 dry extract of ginger 6-25 dry extract of turmeric 5-24 dry extract of white peony 2-20 dry extract of Rhodiola Rosea 2-20 dry extract of apricot seed 5-20 dry extract of oyster mushroom 10-34 dry extract of green tea 12-35 dry extract of Ginkgo Biloba 2-25 dry extract of white pepper 1-15 dry extract of pomegranate pulp 2-20 extract of medlar 2-20 dry powder of pomegranate juice 2-25 folic acid 3-30

Compositions and methods are presented that help reduce cellular ageing, improve cellular stress resilience, and/or promote increased longevity. Especially preferred compositions include a combination of a purine alkaloid, an isothiocyanate or thioglucoside, and a metal-containing antioxidant, where the purine alkaloid, the isothiocyanate or thioglucoside, and the metal-containing antioxidant may be chemically isolated compounds or extracts or other preparations from naturally occurring entities such as plants, bacteria, yeast, etc. Advantageously, contemplated compositions will be effective to reduce and repair oxidative stress, improve mitochondrial function, augment DNA repair and telomere maintenance, increase fatty acid metabolism, and modulate histone deacetylation.

Compositions and methods are presented that help reduce cellular ageing, improve cellular stress resilience, and/or promote increased longevity. Especially preferred compositions include a combination of a purine alkaloid, an isothiocyanate or thioglucoside, and a metal-containing antioxidant, where the purine alkaloid, the isothiocyanate or thioglucoside, and the metal-containing antioxidant may be chemically isolated compounds or extracts or other preparations from naturally occurring entities such as plants, bacteria, yeast, etc. Advantageously, contemplated compositions will be effective to reduce and repair oxidative stress, improve mitochondrial function, augment DNA repair and telomere maintenance, increase fatty acid metabolism, and modulate histone deacetylation.

It is provided an anti-aging composition comprising at least one plant extract and a carrier, the at least one plant extract is at least one of Serenoa repens, Hypericum perforatum, Ilex paraguariensis, Ocimum tenuiflorum, Solidago virgaurea, Citrus sinensis, Humulus lupulus, Vitis vinifera, Andrographis paniculata, Hydrastis canadensis, Trigonella foenum-graecum, Berberis vulgaris, Crataegus monogyna, Taraxacum erythrospermum, Ilex paraguariensis, and a combination thereof.

It is provided an anti-aging composition comprising at least one plant extract and a carrier, the at least one plant extract is at least one of Serenoa repens, Hypericum perforatum, Ilex paraguariensis, Ocimum tenuiflorum, Solidago virgaurea, Citrus sinensis, Humulus lupulus, Vitis vinifera, Andrographis paniculata, Hydrastis canadensis, Trigonella foenum-graecum, Berberis vulgaris, Crataegus monogyna, Taraxacum erythrospermum, Ilex paraguariensis, and a combination thereof.

It is provided an anti-aging composition comprising at least one plant extract and a carrier, the at least one plant extract is at least one of Serenoa repens, Hypericum perforatum, Ilex paraguariensis, Ocimum tenuiflorum, Solidago virgaurea, Citrus sinensis, Humulus lupulus, Vitis vinifera, Andrographis paniculata, Hydrastis canadensis, Trigonella foenum-graecum, Berberis vulgaris, Crataegus monogyna, Taraxacum erythrospermum, Ilex paraguariensis, and a combination thereof.

Embodiments described herein provide for uses of grape products, such as Chardonnay grape products and grape seed flour, for use in promoting a healthy liver, promoting healthy fat content in a liver, for treating or preventing NAFLD, and other embodiments and uses as described herein.

Embodiments described herein provide for uses of grape products, such as Chardonnay grape products and grape seed flour, for use in promoting a healthy liver, promoting healthy fat content in a liver, for treating or preventing NAFLD, and other embodiments and uses as described herein.

Embodiments described herein provide for uses of grape products, such as Chardonnay grape products and grape seed flour, for use in promoting a healthy liver, promoting healthy fat content in a liver, for treating or preventing NAFLD, and other embodiments and uses as described herein.

Provided are methods for inhibiting immune responses against microbial antigens. In some embodiments, the methods include administering to the subject a composition containing a plurality of plant-derived exosome-like particles to inhibit immune esponses against microbial antigens. Also provided are methods for inhibiting development of septic shock in subjects, for inhibiting development of cytokine storm in subjects, and for inhibiting SARS-CoV-2-induced cytopathogenic effect. Also provided are compositions that include an exosome-derived nanoparticle comprising a first lipid bilayer and a second lipid bilayer coating the exosome-like nanoparticle and/or fused with the first lipid bilayer, wherein the second lipid bilayer comprises a targeting molecule, and methods for using the compositions to treat diseases, disorders, and conditions and/or to target a therapeutic agent to a cell, tissue, and/or organ of interest.