The present invention provides a method of producing a modified collagen, including the steps of: providing a collagen comprising a SS bond; introducing a SH group in said collagen comprising a SS bond by reduction of the SS bond to provide a collagen thiol comprising a SH group; and nitrosating the SH group of the collagen thiol to provide a modified collagen, said modified collagen comprising S-nitroso groups.

An oral composition which contains a dark-green vegetable and one or more selected from an amino acid, a peptide, and a protein. A method for producing an oral composition, the method containing mixing a dark-green vegetable and one or more selected from an amino acid, a peptide, and a protein.

The invention provides a method for treating subclinical mastitis in a ruminant by orally administering to the ruminant an effective amount of a composition that contains a naturally occurring material derived from eggshell membrane.

This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.

The present invention aids to correct erectile dysfunction by increasing blood circulation on the skin when applied topically. This composition is made with all organic food grade ingredients in form of a lotion than when rubbed on the skin, in a time-controlled fashion, is nutrition for the skin.

The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and/or prevention of a metastatic cancer wherein the agent an extracellular matrix (ECM) protein carried on a polycarbonate polyurethane matrix. The invention also relates to a product, comprising an agent for modulating metastatic tumor cell dissemination, and to a method of treatment or prevention of cancer.

The present invention relates to the use of collagen hydrolysate in the prevention and/or treatment of food craving. The collagen hydrolysate may have a therapeutic and/or non-therapeutic effect. The prevention and/or treatment of craving by the collagen hydrolysate may find purpose in losing bodyweight or improving general well-being. The collagen hydrolysate is preferably administered as a daily food supplement formulation.

The present invention relates to a composition comprising chondroitin sulfate and collagen hydrolysate, for use in ameliorating pain, preferably for use in ameliorating joint pain after exercise. The present invention furthermore relates to a method of preparing said composition by hydrolysis of a collagen-containing material comprising different types of collagen. The composition is preferably administered as a food supplement.

The present invention provides compositions and methods useful in the treatment of wounds, particularly in reducing or preventing scar formation, particularly hypertrophic scar or keloid formation. The invention thus further provides methods of treatment, including methods useful in hypertrophic scar or keloid revision as well as prophylactic, scar inhibiting methods.

The present invention is in the fields of medicinal chemistry, biotechnology and pharmaceuticals. The invention provides compositions comprising one or more collagen mimetic peptides, optionally attached to one or more therapeutic compounds or one or more imaging compounds, for use in methods of treating, preventing, ameliorating, curing and diagnosing certain diseases and physical disorders in humans and veterinary animals, as well as methods of manufacturing such composition. The invention also provides medical devices comprising one or more such compositions of the invention. The invention also provides methods of use of such compositions and devices in treating and diagnosing certain diseases and physical disorders in humans and veterinary animals, including ocular diseases or disorders, skin diseases or disorders, certain cancers, particularly intraluminal cancers, gastrointestinal diseases or disorders, genitourinary tract diseases or disorders, fibrotic diseases/disorders and rheumatic diseases/disorders.