The subject of the application is keratin hydrolyzates which are characterized by a minimum amount of protein fragments having molecular weights of less than 1000 Da, enzymatic methods for the preparation thereof and also the use thereof in hair treatment compositions and also in cleansing compositions for skin and hair.

Provided are pharmaceutical foam compositions comprising a peptone, a peptide hydrolysate or an enzymatically-hydrolyzed protein prepared by enzymatic hydrolysis of a full-length protein; methods of preparation and uses thereof.

The invention generally relates to pharmaceuticals and/or nutraceuticals. More particularly, the invention provides compositions of collagen-based peptides and specific digestive tract microbes useful for supporting or promoting joint, skin and/or bone health, and methods of preparation and use thereof. The invention further provides for the use of compositions of collagen-based peptides as a prebiotic for modulating the gut microbiome.

A method of increasing muscle mass and strength in mammals by orally administering a therapeutically effective amount of phosphatidic acid. The phosphatidic acid is preferably administered as a plurality of doses per day with at least one dose being administered during the anabolic window following exercise. Preferably, the method further includes the cotemporaneous administration of a therapeutically effective amount of creatine, optionally as phosphatidylcreatine. In addition or in the alternative, the method further includes the cotemporaneous administration of a therapeutically effective amount of leucine, optionally as phosphatidylleucine.

The present invention concerns a method of generating a population of skeletal muscle derived human muscle precursor cells. For this purpose, a specialized FBS-free cell growth medium is used. The invention further concerns a composition comprising such a population of hMPCs for use as a medicament, especially in the treatment of skeletal muscle dysfunction.

Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an esophagus of a subject. These methods include injecting submucosally into the esophagus of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the esophagus, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the esophagus; and c) a stiffness of about 10 to about 400 Pascal (Pa). The ECM hydrogel is not a urinary bladder ECM hydrogel.

A growth-promoting supplement for livestock is a meal additive for hair growth, tail growth, and nail growth. The growth-promoting supplement also promotes hair, tail, and nail strength. The growth-promoting supplement includes a quantity of gelatin, a quantity of Biotin, a quantity of Lysine, a quantity of Vitamin E, and a quantity of Methionine. The composition is heterogeneously mixed into a powdered mixture that may be mixed into a meal for livestock. The composition further includes a quantity of alfalfa powder. Alternatively, the composition further includes a quantity of current-health-based additives. The current-health-based additives includes a quantity of Vitamin C, a quantity of Zinc, a quantity of Omega-3 fatty acids, and combinations thereof. Both the quantity of alfalfa powder and the quantity of current-health-based additives are heterogeneously mixed into the powdered mixture according the specific dietary needs and health condition of the livestock.

A growth-promoting supplement for livestock is a meal additive for hair growth, tail growth, and nail growth. The growth-promoting supplement also promotes hair, tail, and nail strength. The growth-promoting supplement includes a quantity of gelatin, a quantity of Biotin, a quantity of Lysine, a quantity of Vitamin E, and a quantity of Methionine. The composition is heterogeneously mixed into a powdered mixture that may be mixed into a meal for livestock. The composition further includes a quantity of alfalfa powder. Alternatively, the composition further includes a quantity of current-health-based additives. The current-health-based additives includes a quantity of Vitamin C, a quantity of Zinc, a quantity of Omega-3 fatty acids, and combinations thereof. Both the quantity of alfalfa powder and the quantity of current-health-based additives are heterogeneously mixed into the powdered mixture according the specific dietary needs and health condition of the livestock.

The invention provides the use of low molecular weight collagen hydrolysate for reducing joint pain such as in arthritis or osteoarthritis.

A pharmaceutical composition contains an integrin binding fragment for Laminin which is selected from the group consisting of Laminin 511 and Laminin 411 for treating or preventing a disease, disorder, or symptom of a tooth dentin and/or pulp or pulp tissue. A method of producing a hard tissue transplantation material includes the steps of culturing odontoblast in the presence of an integrin binding fragment for the Laminin which selected from the group consisting of Laminin 511 and Laminin 411 and obtaining a culture of odontoblast and inducing calcification or mineralization of the culture of odontoblast so as to obtain the hard tissue transplantation material.