Provided herein are compositions comprising a calcineurin inhibitor and a nonsteroidal anti-inflammatory drug (NSAID) and related methods of administering such compositions for preventing post-ERCP pancreatitis (PEP).

Provided herein are compositions comprising a calcineurin inhibitor and a nonsteroidal anti-inflammatory drug (NSAID) and related methods of administering such compositions for preventing post-ERCP pancreatitis (PEP).

Methods, compositions and kits for reducing renal tissue toxicity in a subject caused by a kidney damaging agent are provided. The methods comprise administering to the subject: (i) a kidney damaging agent; (ii) a PPARA activator; and (iii) an inhibitor of a cellular pathway selected from the group consisting of C/EBP, PPARG, ER stress, GLUT2 and SGLT1/2; or (i) a kidney damaging agent; (ii) a SGLT2 inhibitor; and (iii) a PPARA activator, a C/EBP inhibitor, a PPARG inhibitor, or an ER stress inhibitor.

Methods, compositions and kits for reducing renal tissue toxicity in a subject caused by a kidney damaging agent are provided. The methods comprise administering to the subject: (i) a kidney damaging agent; (ii) a PPARA activator; and (iii) an inhibitor of a cellular pathway selected from the group consisting of C/EBP, PPARG, ER stress, GLUT2 and SGLT1/2; or (i) a kidney damaging agent; (ii) a SGLT2 inhibitor; and (iii) a PPARA activator, a C/EBP inhibitor, a PPARG inhibitor, or an ER stress inhibitor.

Methods, compositions and kits for reducing renal tissue toxicity in a subject caused by a kidney damaging agent are provided. The methods comprise administering to the subject: (i) a kidney damaging agent; (ii) a PPARA activator; and (iii) an inhibitor of a cellular pathway selected from the group consisting of C/EBP, PPARG, ER stress, GLUT2 and SGLT1/2; or (i) a kidney damaging agent; (ii) a SGLT2 inhibitor; and (iii) a PPARA activator, a C/EBP inhibitor, a PPARG inhibitor, or an ER stress inhibitor.

The present invention is directed to an aerosol foam composition comprising roflumilast, an emulsifier blend containing cetearyl alcohol, dicetyl phosphate, and ceteareth-10 phosphate and a hydrocarbon propellant. The aerosol foam composition is preferably an oil in water emulsion. The propellant is a mixture of liquefied hydrocarbon gases preferably a propane/isobutane/butane blend. The hydrocarbon propellant results in an aerosol foam which is stable, has consistent physical properties, excellent aesthetics, and no discernable degradation after long term or accelerated storage conditions.

The present invention is directed to an aerosol foam composition comprising roflumilast, an emulsifier blend containing cetearyl alcohol, dicetyl phosphate, and ceteareth-10 phosphate and a hydrocarbon propellant. The aerosol foam composition is preferably an oil in water emulsion. The propellant is a mixture of liquefied hydrocarbon gases preferably a propane/isobutane/butane blend. The hydrocarbon propellant results in an aerosol foam which is stable, has consistent physical properties, excellent aesthetics, and no discernable degradation after long term or accelerated storage conditions.

The present invention relates to a composition for preventing, improving or treating psoriasis containing an immunomodulator and glucosamine. Cyclosporine, an immunomodulator, is difficult to administer for a long time due to side effects thereof, and, when the administration of cyclosporine is discontinued, lesions tend to deteriorate to an original state thereof. However, according to the present invention, the co-administration of cyclosporine and glucosamine, even when the dose of cyclosporine is reduced, may exert a far superior effect on the treatment or improvement of psoriasis than the administration of cyclosporine and glucosamine alone.

The present invention relates to a composition for preventing, improving or treating psoriasis containing an immunomodulator and glucosamine. Cyclosporine, an immunomodulator, is difficult to administer for a long time due to side effects thereof, and, when the administration of cyclosporine is discontinued, lesions tend to deteriorate to an original state thereof. However, according to the present invention, the co-administration of cyclosporine and glucosamine, even when the dose of cyclosporine is reduced, may exert a far superior effect on the treatment or improvement of psoriasis than the administration of cyclosporine and glucosamine alone.

The present disclosure relates to methods of treatment or prevention of ocular conditions caused by treatment with certain therapeutically active agents. The methods can include administering a cyclosporine, an analog or derivative thereof, or a combination thereof to an eye of a mammal suffering from an ocular condition cased by treatment with certain therapeutically active agents, which can include a chemotherapy agent or an antiviral agent.