The present invention includes a composition including as one component a slurry matrix that is a liquid at room temperature and a gel at physiological pH, physiological salt concentrations and/or physiological temperatures and as a second component one or more antigens. Also include are methods of inducing an immune response in a subject and vaccinating a subject by administering such compositions.

Provided are compositions comprising chemically synthesized pseudaminic acid (Pse) conjugated to a carrier protein using the OPA chemistry, methods of using said compositions to stimulate immune responses in subjects and protect the vaccinated subjects from infections caused by Pse-producing A. baumannii.

The present invention relates to compositions comprising Moraxella catarrhalis (M. catarrhalis) Ubiquitous surface protein A2 (UspA2). More particularly, the present application relates to UspA2 protein constructs and immunogenic compositions comprising the constructs, vaccines comprising such immunogenic compositions and therapeutic uses of the same. The invention further relates to compositions comprising UspA2 in combination with at least one antigen from Haemophilus influenzae, immunogenic compositions comprising the antigens, vaccines comprising such immunogenic compositions and therapeutic uses of the same.

Compositions and methods are provided for reducing the transmission of at least one pathogen including S. pneumoniae through administration to subjects of immunogenic compositions comprising a recombinant, live attenuated S. pneumoniae expressing on its cell surface at least one heterologous immunogenic protein, or an immunogenic fragment or variant thereof. The immunogenic compositions also serve to reduce the incidence rate of at least one disease, such as acute otitis media, caused by at least one pathogen. Examples of heterologous immunogenic proteins, or immunogenic fragments or variants thereof, include H. influenzae protein D and M. catarrhalis UspA polypeptide. The expressed heterologous immunogenic protein, or an immunogenic fragment or variant thereof, is modified with a surface anchor moiety for anchoring at the cell surface of S. pneumoniae.