A61K39/25

Non-neuroinvasive viruses and uses thereof

Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.

Non-neuroinvasive viruses and uses thereof

Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.

VACCINES, VACCINE PRIMING, AND ANTIGEN DOSE SPARING
20230263886 · 2023-08-24 ·

The present application relates to new vaccines, improved vaccine priming, and antigen dose sparing in connection with triterpene glycoside saponin-derived adjuvants, salt forms thereof, and pharmaceutical compositions, as well as related methods.

VACCINES, VACCINE PRIMING, AND ANTIGEN DOSE SPARING
20230263886 · 2023-08-24 ·

The present application relates to new vaccines, improved vaccine priming, and antigen dose sparing in connection with triterpene glycoside saponin-derived adjuvants, salt forms thereof, and pharmaceutical compositions, as well as related methods.

Recombinant virus with diminished latency and methods of using same

The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.

Recombinant virus with diminished latency and methods of using same

The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.

NUCLEIC ACID VACCINES FOR VARICELLA ZOSTER VIRUS (VZV)

Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include at least one RNA polynucleotides having an open reading frame encoding at least one varicella zoster virus (VZV) antigen. Methods for preparing and using such vaccines are also described.

NUCLEIC ACID VACCINES FOR VARICELLA ZOSTER VIRUS (VZV)

Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include at least one RNA polynucleotides having an open reading frame encoding at least one varicella zoster virus (VZV) antigen. Methods for preparing and using such vaccines are also described.

Broadly neutralizing anti-human cytomegalovirus (HCMV) antibodies and methods of use thereof

The present disclosure relates to anti-human cytomegalovirus (anti-HCMV) antibodies and vaccines as well as diagnostic and therapeutic methods of use.

Broadly neutralizing anti-human cytomegalovirus (HCMV) antibodies and methods of use thereof

The present disclosure relates to anti-human cytomegalovirus (anti-HCMV) antibodies and vaccines as well as diagnostic and therapeutic methods of use.