Compositions and methods are provided for potent mRNA vaccines for prevention and treatment of 2019 novel Coronavirus (2019-nCoV) infections. The compositions include a pharmaceutical composition containing one or more mRNA molecules encoding spike protein epitopes, including mutated epitopes, or mRNA cocktails that encode critical viral genes together with pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Methods for stimulating system immune responses and treatment are provided, including subcutaneous, intraperitoneal and intramuscular injections.

The present invention relates to a live attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for prophylaxis or treatment of an allergen-driven airway pathology.

The present application relates to methods and compositions employing an antibody that inhibits activation of the complement system and can be used to prevent or treat a pulmonary disease or condition.

Compositions comprising mRNA formulated for pulmonary administration and related method for delivery of the mRNA and/or encoded protein to a non-lung cell or tissue. The compositions and methods may be used to prevent or ameliorate the symptoms of diseases associated with the mRNA encoded protein.

The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.

This application relates to compositions comprising one or more CpG oligodeoxynucleotides complexed to nanoparticles comprising a gemini surfactant and optionally a muco-adhesive polymer, which can be used for intrapulmonary delivery to induce immunity in feed animals, and the methods of making and uses thereof.

A vaccine formation and delivery system includes a first chamber configured to store a live virus and a second chamber for storing an inactivated virus. The system further includes a UV radiation means used for irradiating the live virus. Personal dosage transfer chambers and a delivery system configured to attach to the personal dosage transfer chambers for delivering an activated virus to a user.

Methods and compositions for treating a viral infection, where the cells from the host to be treated are extracted from the host and modified with viral DNA, and then replaced back to the host to generate an immune response. The composition may be produced using fat cells that are mechanically or chemically transformed to a nanofat, and co-incubation of the nanofat with the adenovirus. The double-stranded DNA of the adenovirus codes for a specific antibody to be produced, and the transfer of genetic material from the virus to the nanofat stem cells takes place outside of the host where the host immune system cannot destroy it. The co-incubated cells are then administered to the host by introduction into the nasal passages or directive cavity, or through injection or other vehicle. The compositions provide an effective rapid response to an invasive pathogen, such as an adenovirus or bacteria, through passive immunity.

The disclosure relates to an extended-range spray applicator, and methods of making and use thereof, for dosing vaccines and/or probiotics to avian animals at a distance.

A method and system for the treatment of honey bees (Apis mellifera), bats, and butterflies protects them from various life threatening conditions, including Colony Collapse Disorder and in particular, provides honey bees with the ability to assimilate and degrade pesticides such as neonicotinoids and fipronil.