Provided is a capsule having a shell of material that is a supramolecular cross-linked network. The network is formed from a host-guest complexation of cucurbituril (the host) and one or more building blocks comprising suitable guest functionality. The complex non-covalently crosslinks the building block and/or non-covalently links the building block to another building block thereby forming the supramolecular cross-linked network. The capsules are obtained or obtainable by the complexation of a composition comprising cucurbituril and one or more building blocks having suitable cucurbituril guest functionality thereby to form a supramolecular cross-linked network.

The invention in suitable embodiments is directed to purified clathrin protein therapeutics. In one aspect, one or more purified clathrin protein therapeutic composition, formed in whole or in part from isolated, synthetic and or recombinant amino acid residues comprising in whole or in part one or more clathrin heavy chain protein and isoforms thereof, forms one or more type of therapeutic agent for treating various types of a cancerous disease, condition, or disorder in vivo or in vitro.

Crystalline cellulose gels useful in the stabilization of emulsions, including nanoemulsions, and for acting as cryptands or clathrates, and methods for their use and production are provided. In some embodiments, the emulsion is an oil-in-water emulsion. In some embodiments, such emulsions and/or vesicles produced in such emulsions, and/or the crystalline cellulose gel itself 15 are useful in the fields of drug delivery, pharmaceuticals, cosmetics, feed and food, paints and coatings, mining, or oil and gas recovery.

The present invention is directed to additive manufacturing compositions and methods for producing additive manufacturing composite blends with oxidized discrete carbon nanotubes with dispersion agents bonded to at least one sidewall of the oxidized discrete carbon nanotubes. Such compositions are especially useful when radiation cured, sintered or melt fused.

Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (off) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (on) the bioactive peptide or binding domain, components of such protein switches, and their use.

Disclosed are an oxidation-responsive water-soluble cationic pillararene, and a preparation method and application thereof, the oxidation-responsive water-soluble cationic pillararene is a cyclic small-molecule nucleic acid vector, and is obtained by quaternization reaction of 4-methylborate and tertiary amine-modified pillararene. According to the invention, a delivery vector with a high positive charge density is obtained through small molecule synthesis, the delivery vector is capable of being tightly complexed with negatively charged nucleic acid substances to form a nano-composite, and after the nano-composite enters cells, vector positive charges fall off to release the nucleic acid substances in an oxidation environment, and nucleic acid is efficiently translated and expressed. The delivery vector has the characteristics of simplicity and convenience in synthesis, high delivery efficiency and good biological safety, and has a good application prospect.

Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (off) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (on) the bioactive peptide or binding domain, components of such protein switches, and their use.

The present invention provides an aqueous ticagrelor composition with improved storage stability comprising ticagrelor as active ingredient and a solubilizer for ticagrelor, preferably a cyclodextrin or vitamin E TPGS. The aqueous ticagrelor solution is preferably provided for intravenous administration, either by injection or infusion. Preferably an aqueous ticagrelor intravenous composition according to the invention, in a ready-to-use form or suitable for dilution prior to intravenous administration, is used as a medicine in the treatment of a ticagrelor responsive disease.

Described herein are polyhedral, three-dimensional tunable nanocages assembled with a multimeric protein covalently linked to a polynucleotide handle and a DNA origami base assembly including sequences complementary to the polynucleotide handles, wherein the polynucleotide handle and the complementary sequences hybridize to for double-stranded DNA helices.

The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.