A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.

A pharmaceutical composition, a combination product including the composition and a method of manufacturing the composition. The composition includes a particulate complex of API bound with a crosslinked polysaccharide micro sponge. The combination product includes a dosage form of the particulate complex within a container. The amount of the particulate complex is selected to provide a defined dose of the API. The formulation may be heated within the container by a vaporizer device, vaporizing the API and dissociating the API from the micro sponge as vapour, which passes through apertures in the container facilitating administration of the API by inhalation of the vapour. The apertures are sized to facilitate passage of the vapour but prevent passage the particulate complex. The API may be hydrophobic such as phytocannabinoids or hydrophilic such as nicotine. The pharmaceutical composition may be manufactured by driving binding of the API to the micro sponge in solution.

A catheter comprises an elongated carrier and a balloon carried by the carrier in sealed relation thereto. The balloon has an outer surface and is arranged to receive a fluid therein that inflates the balloon. The catheter further comprises a shock wave generator within the balloon that forms mechanical shock waves within the balloon, and a medicinal agent carried on the outer surface of the balloon. The medicinal agent is releasable from the balloon either before or in response to the shock wave.

The invention relates to oligofluorinated coatings and their use in drag delivery. The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue. This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface.

The present invention provides an implant comprising an isotope capable of producing a dose of ionizing radiation upon exposure to a flux of low energy neutrons, and a method in which, after implantation, the implant is exposed to a flux of low energy neutrons to control or treat infections.

The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (HA). The biomaterial compositions utilize small HA binding peptides and extracellular matrix binding (ECM) peptides that are tethered to synthetic biocompatible polymers. When tethered to the polymers, the peptide region allows the polymers to bind to HA and to tissues such as cartilage. The novel biomaterial compositions can be used to coat or chemically modify cartilage or tissues with a biologically compatible polymer having HA binding peptides, which allow HA to bind to the surface of the cartilage or tissues. Methods of using same are also provided.

This invention relates, e.g., to a molecular delivery system comprising A. a substrate having a nanostructured surface region which comprises a plurality of nanostructures and, covalently attached to the substrate, multiple copies of a first member of a binding pair; and B. at least one vector nanoparticle which comprises, encapsulated therein, a molecule of interest, and on its surface, multiple copies of second member of the binding pair. Methods of using the molecular delivery system to deliver a molecule of interest to a cell are also described.

Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (II). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

The invention relates to a method for producing eye drops, the thus obtained eye drops and to a kit which comprises the eye drops.

The present invention relates to an optical fiber and a device including the optical fiber. The optical fiber is an optical fiber (1) functionalized with at least one particle (1) of a polymeric gel comprising at least one photosensitive molecule (7) and at least one biomolecule (6), wherein the at least one particle (2) of the polymeric gel is covalently bound to said optical fiber (1).