A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.

A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.

A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.

A magnetite-based micro/nanorobot and a preparation method and use thereof are provided. The magnetite-based micro/nanorobot uses a polydopamine-coated magnetite as a carrier that is loaded with an anti-inflammatory drug and is finally coated with sodium alginate. The magnetite-based micro/nanorobot of the present disclosure improves a loading effect of the drug resveratrol and has an excellent anti-inflammatory effect. The magnetite-based micro/nanorobot of the present disclosure does not have obvious cytotoxicity, and exhibits excellent biocompatibility and high safety performance. The magnetite-based micro/nanorobot of the present disclosure allows the responsive release according to different pH values of a gastrointestinal environment. Compared with the traditional drug carriers, the magnetite-based micro/nanorobot of the present disclosure has a high rate and prominent targetability, and can be prepared by a method involving simple steps and easy operations.

Alpha-sheet polypeptide multimers, and polypeptides for making multimers, compositions and medical devices including them, and their use for treating and diagnosing amyloid diseases or amyloid-associated diseases are disclosed.

Compositions and methods for coating medical devices are provided. A coating composition may comprise a tether covalently attached to an anti-microbial peptide, the tether having sufficient length to permit the anti-microbial peptide to at least partially penetrate a membrane of a bacteria, upon contact of the anti-microbial peptide with the bacteria.

Methods, devices and systems are disclosed for chemically bonding antibiotics to selected substrate materials which are not dissolved in normal physiological processes so that high local concentrations can be achieved during the inflammatory response. The antibiotics will remain permanently bonded to the substrate material until an infection occurs which releases the antibiotic in high concentrations to help control the infection. The high local concentrations may be much higher than systemic toxic levels, and can never reach toxic levels because the local dose is much less than needed to reach systemic toxicity if completely dissolved.

Ocular drug delivery device and related methods. The ocular drug delivery device includes a contact lens having a curvature configured to fit a cornea of an eye, an array of silicon nanoneedles attached to and protruding from a surface of the contact lens, and a therapeutic drug cargo loaded onto individual nanoneedles of the array of silicon nanoneedles. A method of releasing a therapeutic drug cargo to an eye with the ocular drug delivery device includes applying the ocular drug delivery device to the eye such that the surface of the contact lens contacts the cornea of the eye and individual nanoneedles of the array of nanoneedles are inserted into the cornea. The contact lens dissolves while leaving the individual nanoneedles inserted in the cornea. The individual nanoneedles degrade in the cornea over time causing release of the therapeutic drug cargo loaded thereon.

The present invention provides an implant comprising an isotope capable of producing a dose of ionizing radiation upon exposure to a flux of low energy neutrons, and a method in which, after implantation, the implant is exposed to a flux of low energy neutrons to control or treat infections.

A microneedle device including a base and a plurality of microneedles is provided. The microneedles are arranged on a surface of the base, wherein the material of the base and the microneedles include polyglutamic acid and pullulan. The ratio of the weight of polyglutamic acid to the weight of pullulan is ranged from 0.1 to 0.9. The microneedle device dissolves quickly and is easy to prepare.