In some aspects, the present disclosure provides a dual emissive pH response noble metal nanoparticle which produces a ratiometric fluorescence signal based upon changes in the pH. In another aspect, the noble metal nanoparticle may be used in bioimaging applications as well as to detect in vivo changes of pH.

Described herein are cyclic peptides, nanoparticles bound with cyclic peptides, and methods for using said cyclic peptides and/or said nanoparticles bound with cyclic peptides for intraoperative nerve tissue imaging.

This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the nanoparticle and wherein a catalytic domain of a protease is linked to the nanoparticle. In certain embodiments, the targeting molecule and the catalytic domain are within a single polypeptide sequence. In certain embodiments, the targeting molecule binds a molecule more highly expressed on cancer cells then non-cancerous cells, and the nanoparticles disclosed herein are used for the treatment of cancer by further attaching an anti-cancer agent to the nanoparticle or incorporating an anticancer agent within the nanoparticle.

There is described a method for delivering exogenous biomolecules into an eye. The method generally has the steps of injecting, into a region of the eye, a mixture having a plurality of exogenous biomolecules and a plurality of plasmonic structures, the plasmonic structures having a plasmonic resonance wavelength, the plasmonic structures adjoining membranes of target cells in said region due to said injecting; and irradiating said region of said eye with a laser beam having a wavelength being offset to said plasmonic resonance wavelength, said irradiating causing the plasmonic structures to form pores in said membranes of said target cells, allowing at least some of the exogenous biomolecules to be delivered into the target cells via said pores.

A bioprobe for a non-invasive diagnosis of Parkinson's disease triggered by an intestinal microenvironment, a preparation method thereof and use thereof are provided. The preparation method for the bioprobe provided by the present invention includes the following steps: (1) mixing europium nitrate with an organic ligand, and synthesizing a luminescent metal organic framework by a solvothermal method; (2) subjecting gold nanoparticles to a mixing reaction with aptamers to obtain Au-aptamer complexes; and (3) dissolving the luminescent metal organic framework in an Au-aptamer complex solution for a reaction, and washing the reaction product sequentially with deionized water, an ethanol solution, and a sodium dodecyl sulfate solution after the reaction to obtain the bioprobe. The present non-invasive oral bioprobe based on an intestinal microenvironment is configured for diagnosis of Parkinson's disease at an early stage.

A composition comprises an anti-nucleolin agent conjugated to nanoparticles, and optionally containing gadolinium. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier. The composition enhances the effectiveness of radiation therapy, enhancing contrast in X-ray imaging techniques, and when gadolinium is present, provide cancer selective MRI contrast agents.

An object is to provide a method of inspection enabling a slurry of a batch resulting in abnormal accumulation to be identified in advance, and to provide an SWCNT slurry for bioimaging that has undergone the inspection.

In order to solve the above problems, the present invention provides a method for inspecting a semiconductor single-walled carbon nanotube (SWCNT) slurry for bioimaging, the slurry comprising: semiconductor SWCNTs oxidized by being directly irradiated with ultraviolet rays in atmosphere and a dispersant composed of an amphiphilic substance that coats surfaces of the SWCNTs, the method comprising: using at least two types of methods selected from the group consisting of absorption spectroscopy, a photoluminescence method, and particle size measurement, confirming that an average particle size of the semiconductor SWCNTs is smaller than 10 nm, isolated dispersibility of the semiconductor SWCNTs is high, and/or the semiconductor SWCNTs are oxidized.

A composition comprises an anti-nucleolin agent conjugated to nanoparticles, and optionally containing gadolinium. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier. The composition enhances the effectiveness of radiation therapy, enhancing contrast in X-ray imaging techniques, and when gadolinium is present, provide cancer selective MRI contrast agents.

An object is to provide an SWCNT slurry for bioimaging with reduced toxicity that causes no aggregation of semiconductor SWCNTs, no accumulation in a specific site when administered to a living organism, and no clogging in blood vessels such as those in the lungs. In order to achieve the above-described object, a semiconductor single-walled carbon nanotube (SWCNT) slurry for bioimaging according to the present invention includes: semiconductor SWCNTs having an average particle size of less than 10 nm; and a dispersant composed of an amphiphilic substance that coats the surfaces of the SWCNTs.

Corona Phase Molecular Recognition (CoPhMoRe) utilizing a template heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte can be used for macromolecular analytes, including proteins.