The invention relates to a functional wound dressing being able to detect and indicate the state of the wound, in particular with regard to an infection which is reported to be frequently associated with poorly healing wounds, such as chronic wounds. The present wound dressing can be used in moist wound healing and contains a substance being able to absorb wound exudate from the wound and to provide moisture to the wound.

A method and system are provided for detecting pancreatic trauma in a trauma patient during a surgical operation. The method includes positioning a detection device in contact with the patient's pancreas, applying a chemical indicator to the detection device after removing the detection device from the patient, and detecting a chemical reaction on the detection device that is indicative of the pancreas releasing an enzyme as a result of pancreatic trauma.

The present disclosure relates to ratiometric detection compositions comprising a reference dye and a sensor dye that are PEGylated dyes, and microneedles comprising said compositions. The present disclosure further relates to methods of ratiometric detection/measurement/monitoring of analytes in a subject using the ratiometric detection compositions of the present disclosure.

Microneedle patches have been developed that can be used to deliver therapeutic, prophylactic, diagnostic agents and/or dyes to the skin. The microneedles encapsulate the agent(s) to be delivered. These are formed of a biodegradable polymer that dissolves upon insertion into skin or tissue, so that the microneedles break off from the substrate forming the patch, remaining in the skin/tissue at the site of insertion. The patches are used to create a tattoo or to deliver therapeutic, prophylactic or diagnostic agent in combination with a tattoo. In one embodiment, the microneedle patch contains both vaccine and dye pigments to administer vaccine and record such administration in one application of the microneedle patch.

A method and system to prevent sore throat infections in humans includes the administration of an active ingredient to a site on the mucus membranes of the throat of a human that inhibits adherence and promotes desorption of S. pyogenes to soft tissue surfaces, such as the pharyngeal and oral mucosa of a human. A mucoadhesive strip having a surface topography that resists bioadhesion of undesired bacteria that are typically present in a human's mouth is preferably employed and that has one or more encapsulated agents selected from the group consisting of an antibiotic; lactic acid bacteria; S. pyogenes modified by a CRISPR-Cas system to reduce one or more virulence factors; and a breath mint solution.

A method and system to prevent sore throat infections in humans includes the administration of an active ingredient to a site on the mucus membranes of the throat of a human that inhibits adherence and promotes desorption of S. pyogenes to soft tissue surfaces, such as the pharyngeal and oral mucosa of a human. A mucoadhesive strip having a surface topography that resists bioadhesion of undesired bacteria that are typically present in a human's mouth is preferably employed and that has one or more encapsulated agents selected from the group consisting of an antibiotic; lactic acid bacteria; S. pyogenes modified by a CRISPR-Cas system to reduce one or more virulence factors; and a breath mint solution.

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.