Provided are MR images of a subject gastrointestinal tract structure in which the lumen of the structure is usefully darkened on both T1-weighted and T2-weighted images when the structure is imaged following administration to the subject of an enteric contrast agent formulation with particles containing encapsulated gas or partial vacuum. The present invention provides an encapsulated gas or partial vacuum particle contrast medium of use in acquiring such MR images. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water.

A significant enhancement of detection capabilities of the room temperature MPQ is seen using optical lithography-defined, ferromagnetic iron-nickel alloy microdisks. Irreversible transitions between strongly non-collinear (vortex) and a collinear single domain states, driven by an ac magnetic field, translate into a nonlinear magnetic response that enables ultrasensitive detection of material at relatively small magnetic fields.

Methods and apparatus for the study of gastrointestinal transit in a human or animal subject. The method being for the study of a subject which has previously ingested a container containing first and second fluids that are detectable and distinguishable by MRI, which method comprises the steps of forming a first magnetic resonance image of at least a portion of the subject's GI tract in which the container is located, wherein the magnetizations of the first and second fluids are in-phase; forming a second magnetic resonance image, coincident with the first image, wherein the magnetizations of the first and second fluids are out-of-phase; and subtracting the second image from the first image, or vice versa, to form a composite image.

Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.

The present invention relates to a MRI contrast agent for a liver cancer-specific imaging diagnosis including manganese silicate which releases manganese ion (Mn.sup.2+) under acidic conditions, and a method of characterizing liver tissue using the MRI contrast agent. In a relatively short time, T1-weighted images show different patterns depending on the tissue-specificity such as vascularity, cell density, mitochondrial activity, hepatocellular affinity and the like in normal liver tissues and lesion liver tissues (especially hepatic tumors), and thus, the disease-specific characteristics of liver cancers can be analyzed at appropriate times by analyzing the T1-weighted images. It is expected to be very useful for differentiating the liver cancer types or evaluating the therapeutic effect. Furthermore, it is expected to be useful for diagnosing the diseases occurring in organs other than liver based on the tissue-specificity.

The present invention provides a nanoparticle, comprising: a core, wherein the core comprises at least one iron oxide; a shell surrounding the core, wherein the shell comprises at least one polymer; and at least one targeting moiety attached to the shell, wherein the nanoparticle does not comprise boron, for use in methods for detecting and treating cancer in a subject.

The disclosure pertains to conformational epitopes in A-beta, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

The disclosure pertains to methods of treating or preventing a disease or condition associated with and/or induced by soluble A-beta oligomer such as Alzheimer's disease by administering to a subject in need thereof conformation specific and/or selective antibodies or binding fragments thereof and related products.

The present invention relates to a biocompatible nanoparticle and a use thereof and, more specifically, to a biocompatible nanoparticle formed by irradiation an electron beam to an aqueous solution comprising at least one substance selected from the group consisting of a polysaccharide, a derivative thereof and a polyethylene glycol, thereby inducing inter-molecular cross-linking or intra-molecular cross-linking, and to a use of the biocompatible nanoparticle in a drug carrier, a contrast agent, a diagnostic agent or an intestinal adhesion prevention agent or for disease prevention and treatment.