Shielding enzymes are made by modifying the enzyme surface with silica precursors and then depositing silica to a desired thickness while retaining biological activity of the enzyme.

Shielding enzymes are made by modifying the enzyme surface with silica precursors and then depositing silica to a desired thickness while retaining biological activity of the enzyme.

Embodiments disclosed herein relate to internal combustion engines, combustion systems that include such internal combustion engines, and controls for controlling operation of the combustion engine. The internal combustion engine may include one or more mechanisms for injecting fuel, air, fuel-air mixture, or combinations thereof directly into one or more cylinders, and controls may operate or direct operation of such mechanisms.

Embodiments disclosed herein relate to internal combustion engines, combustion systems that include such internal combustion engines, and controls for controlling operation of the combustion engine. The internal combustion engine may include one or more mechanisms for injecting fuel, air, fuel-air mixture, or combinations thereof directly into one or more cylinders, and controls may operate or direct operation of such mechanisms.

The present invention is directed to a system and method for echogenically enhancing a target site within a patient during a medical procedure. The system includes an imaging system having a display for viewing the target site, a plurality of metallic particles configured to selectively target and bind to one or more locations at the target site, and a delivery mechanism for delivering the plurality of metallic particles into the patient towards the target site. As such, the method includes delivering, via the delivery mechanism, the plurality of metallic particles into the patient and allowing the metallic particles to selectively target and bind to the target site. The method also includes viewing, via a display of an imaging system, the target site with the plurality of metallic particles bound thereto.

A method for early stage pathology detection, location, imaging, evaluation, and treatment of cells and/or extracellular vesicles in the circulation.

Biocompatible polymeric nanoparticles may include: a biocompatible polymer and/or functional metal nanostructures. The biocompatible polymer may be a polyhydroxyalkanoate (PHA). The functional metal nanostructures may include at least one noble metal, at least one magnetic metal oxide, or mixtures thereof. The biocompatible polymeric nanoparticles may have an average size less than or equal to 200 nanometers (nm).

An electromagnetic device, such as an actuator for electrovalves or injectors, particularly for endothermal engines includes a coil winding of an electric wire covered with an insulating layer made of overmoulded plastic material. In order to prevent the electric wire from breaking at the ends thereof connected to the electric terminals, a protective insert is applied prior to the plastic moulding step. The insert is also made of thermoplastic material, so that it can melt locally together with the cover material, thereby ensuring a stable and effective union during the moulding process. The invention also relates to a process for manufacturing the device.

Disclosed are methods, systems, and devices for implementing nanoparticles to encapsulate biomolecules such as enzymes. In one aspect, a nanoparticle device includes a shell structure including an internal layer structured to enclose a hollow interior region and include one or more holes penetrating through the internal layer, and an external layer formed of a porous material around the internal layer; and an enzyme contained within the interior region of the shell structure, the enzyme having entered the shell structure through the one or more holes and incapable of passing through the external layer, in which the pores are of a size that prevents the enzyme to pass through the pores while permitting substances smaller than the pore size to pass through the pores.

The present invention relates to silica hollow nanoparticles having inside their cavity a metal core consisting of inorganic nanostructures coated by a protective agent and agglomerated with a polymeric aggregating agent, useful in particular in medicine in the bio-imaging techniques and/or in the radio-therapeutic or chemo-therapeutic techniques; the invention moreover refers to a process for the preparation of such nanoparticles.