The present invention relates to a pH sensitive particle, a method of preparation thereof, and a use thereof. More particularly, the invention provides a pH sensitive metal nanoparticle and its use for medical treatment utilizing cell necrosis during photothermal therapy. The pH sensitive metal nanoparticle based on this invention consists of a pH sensitive ligand compound whose charge changes depending on the pH of the metal nanoparticle. The particle can be collected in cells, such as cancer cells which present an abnormal pH environment. The pH sensitive metal nanoparticle based on this invention can induce cell death through a photothermal procedure after aggregation. Therefore, the invention enables medical treatment using cell necrosis for e.g. cancer treatment.

This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging.

The disclosure provides a composition comprising a monodispersion of silica glass microspheres infused with a positron emission tomography (PET) radiotracer and a method of making the same. The composition can be used as a positron emission tomography (PET) imaging surrogate for predicting in vivo behavior of therapeutic Y-90 microspheres. Compositions and methods are also described utilizing a therapeutic nuclide. In various examples, the monodispersion of silica glass microspheres can be infused with copper, gallium, or fluorine.

Embodiments herein relate to a cancer therapy delivery system including a cancer therapy delivery assembly or box with adjustment features. In an embodiment, a cancer therapy delivery assembly includes a base, an inner housing disposed over the base, and an outer housing disposed over the inner housing. The outer housing is moveable along a vertical axis relative to the inner housing. The assembly can also include a rotatable component holder disposed on the outer housing and configured to rotate relative to the outer housing. The assembly can also include a transparent shielding member disposed over the rotatable component holder and a catheter support arm attached to the rotatable component holder. The catheter support arm can be configured to adjustably move inward or outward with respect to a center of the cancer therapy delivery assembly. Other embodiments are also included herein.

Embodiments herein relate to cancer therapy delivery systems with improved flow paths and features for preparing the same for use. In an embodiment, a cancer therapy delivery system is included having a carrier fluid delivery device and a first fluid line, wherein the first fluid line is in fluid communication with the carrier fluid delivery device. The system can also include a fluid injector and withdrawal assembly including an inflow conduit and an outflow conduit. The fluid injector and withdrawal assembly is in fluid communication with the first fluid line and a second fluid line. The system can also include a fluid delivery catheter in fluid communication with the second fluid line. The system can also include a jumper device configured to provide a direct fluid flow path between the inflow conduit and the outflow conduit. Other embodiments are also included herein.

The present invention relates to alginate-based gels for use in radiotherapy. More particularly, the invention provides an alginate gel comprising a peptide-coupled alginate, at least one type of divalent cation, and at least one radionuclide cation; a method for providing at least one alginate gel particle; a composition comprising said alginate gel; said alginate gel or composition for use as a medicament; said alginate gel or composition for use in a method for the treatment of a proliferative disease; and kits comprising an alginate and a radionuclide cation.

A method of treating CNS tumors such as gliomas is provided comprising delivering a -emitting radionuclide containing composition to the tumor via the cerebral vasculature.

In the microsphere preparation for chemoembolization therapy and nuclear medicine imaging of tumor, and a preparation method thereof, the microsphere is formed by means of using a polyvinyl alcohol derivative as a framework material and polymerizing, crosslinking and curing same with an N-acryl amino acid monomer. The microsphere can label radionuclide iodine and can also absorb load chemotherapeutic drugs.

A suspension comprising radioactive microspheres. The radioactive microsphere comprises a resin microsphere and a radionuclide loaded on the resin microsphere, wherein the average particle size of the radioactive microsphere is 25 m to 40 m. By means of controlling the proportion of non-spherical microspheres in the radioactive microspheres to be within 5%, the distribution density of the microspheres at a tumor part is increased, the effect of killing tumors is improved, and the treatment safety is improved.

A method of treating CNS tumors such as gliomas is provided comprising delivering a -emitting radionuclide containing composition to the tumor via the cerebral vasculature.