Provided is a composition comprising: (A) a silicone polymer of the Formula (I):

M.sup.1.sub.aM.sup.2.sub.bM.sup.3.sub.cD.sup.1.sub.dD.sup.2.sub.eD.sup.3.sub.fT.sup.1.sub.gT.sup.2.sub.hT.sup.3.sub.iQ.sub.j. wherein: M.sup.1=R.sup.1R.sup.2R.sup.3SiO.sub.1/2 M.sup.2=R.sup.4R.sup.5R.sup.6SiO.sub.1/2 M.sup.3=R.sup.7R.sup.8R.sup.9SiO.sub.1/2 D.sup.1=R.sup.10R.sup.11SiO.sub.2/2 D.sup.2=R.sup.12R.sup.13SiO.sub.2/2 D.sup.3=R.sup.14R.sup.15SiO.sub.2/2 T.sup.1=R.sup.16SiO.sub.3/2 T.sup.2=R.sup.17SiO.sub.3/2 T.sup.3=R.sup.18SiO.sub.3/2 Q=SiO.sub.4/2 where R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.13, R.sup.15, R.sup.16 are independently chosen from a hydrogen, a C.sub.1-C.sub.60 aliphatic or aromatic group or C.sub.1-C.sub.60 alkoxy group; R.sup.4, R.sup.12, R.sup.17 are independently chosen from a C1-C10 alkyl, a C1-C10 alkoxy, or R.sup.19-A-R.sup.20 where A is chosen from a group comprising an unsaturated cyclic moiety chosen from an aromatic group, a fused aromatic group, an unsaturated alicyclic group, an unsaturated heterocyclic group, or a combination of two or more thereof; R.sup.19 is chosen from a H, a C1-C10 alkyl, allyl, vinyl, alkoxy, allyloxy, vinyloxy, acrylate, or methacrylate; and R.sup.20 is chosen from a divalent organic group; R.sup.7, R.sup.14, R.sup.18 are independently selected from hydrogen or OR.sup.22 or unsaturated monovalent radicals or radicals containing heteroatom such as oxygen, nitrogen, sulfur or radicals containing organosilane groups; and
the subscripts a, b, c, d, e, f, g, h, i, j are zero or positive subject to the following limitations: 2a+b+c+d+e+f+g+h+i+j1000, b+e+h>0 and c+f+i0 and
B) a thermally conductive filler.

Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.

The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

The present invention relates to a cooling gel composition comprising methyl diisopropyl propionamide, at least one C2-C5 alcohol, at least one silica aerogel and at least one powder, as well as to systems and methods for making-up and enhancing the appearance of keratinous materials using the cooling gel composition.

A frozen therapeutic dose includes an amniotic material and is configured into a pack for easy administering of the dose to a treatment location. A frozen therapeutic dose may contain a concentration of live amniotic stem cells. A frozen therapeutic dose may be provided in a form, such as a multi-pack form, to enable a person to administer a dose to a treatment location without the need of traveling to a doctor's office or clinic. A frozen therapeutic dose package may be kept in a conventional freezer at 20 C. for example, for extended periods of time and a person may remove the package as needed for treatment. A frozen dose package or pack may contain a secondary material configured to mix with the frozen therapeutic dose. A secondary material may be configured within a single dose compartment with the frozen dose or within a separate compartment.

A method of providing a cooling effect to a product includes the incorporation into the product of at least one compound of the formula I

##STR00001##

in which m is a number between 0 and 2, X, Y and Z are selected independently from the group consisting of H, halogen, OH, Me, Et, MeO and EtO, and R.sup.1, R.sup.2 and R.sup.3 together comprise at least 6 carbons, selected such that (a) (i) R.sup.1 is selected from the group consisting of H, Me, Et, isopropyl and C.sub.4-C.sub.5 branched alkyl; and (ii) R.sup.2 and R.sup.3 are independently selected from the group consisting of Me, Et, isopropyl and C.sub.4-branched alkyl; or (b) any two or all of R.sup.1, R.sup.2 and R.sup.3 together form a monocyclic, bicyclic or tricyclic radical having up to 10 carbons.

The compounds confer substantial cooling effects on compositions applied to the skin or taken orally, such as toothpastes, mouthwashes, foodstuffs, beverages, confectionery, tobacco products, skin creams and ointments.

Suggested are liquid cooling compositions, containing (a) L-Menthol, (b) D-Menthol, and (c) at least one further cooling agent, selected from the group consisting of isomenthol, menthyl acetate (L), menthyl acetate (D), menthyl acetate (iso), acetic acid menthyl lactate (iso) and acetic acid menthyl lactate (neo)
with the proviso that in case that component (c) represents Isomenthol, the compositions do not contain any alkanediols.

Mixtures comprising a selected cooling active ingredient (E)-3-benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide and at least one other substance which acts as a solvent for (E)-3-benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide, wherein the substance is selected form the group consisting of benzyl benzoate, diethyl succinate, triethyl citrate, triacetin, ethanol, peppermint oil, anethol, optamint, propylene glycol, further cooling active ingredients or mixtures thereof.

Disclosed are TRPM8 modulators for achieving a cooling effect on skin and mucousa.