Disclosed herein are methods of making sterilized ciprofloxacin compositions. In some embodiments, the method includes the steps of: (a) forming an aqueous suspension comprising ciprofloxacin particles; (b) heating the aqueous suspension comprising ciprofloxacin particles at a temperature range of from about 100° C. to about 120° C.; and (c) allowing the aqueous suspension comprising ciprofloxacin particles to cool down. Also described herein are otic formulations containing ciprofloxacin formed by the disclosed methods, and therapeutic use of such otic formulation for providing sustained release of ciprofloxacin into the ear for treating various otic disorders and conditions.

A method of preparing containers for blood-derived products includes filling the blood-derived product containers with the blood-derived product, of virally inactivating the blood-derived product containers, and detecting possible defects in the blood-derived product containers. The viral inactivation is carried out by placing the blood-derived product containers in contact with steam at sub-atmospheric pressure in a chamber adapted for that purpose.

A vessel harvesting apparatus for removing a blood vessel from a patient includes collection and conditioning (i.e., treatment) of expelled insufflation gas prior to releasing the gas into the air of the operating room. An endoscopic instrument has a distal end with a vessel harvesting tip and has a proximal end with a handle. An insufflation channel is configured to convey an insufflation gas subcutaneously into a dissected space within the patient. A removal channel is configured to evacuate fluidic contents from the dissected space, wherein the fluidic contents include insufflation gas and biological impurities. A processor/separator is coupled to the removal channel to process the fluidic contents to retain at least some of the biological impurities and to exhaust the insufflation gas.

Methods and devices use one or more of pressure, pressure drop, increased temperature, rate of temperature increase, and inert gas to kill microbes. Utilizing a method or device, liquid is subjected to a pressure drop and heated either during and/or after the pressure drop. The liquid may be heated while in droplet phase, in a liquid volume, or both. Inert gas may be dissolved into the liquid at a pressure greater than 1 Bar. The pressure is later reduced, which causes inert gas to be released from the liquid. Other method steps and processes are also disclosed.

Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented.

Air sterilizer generates ozone through ozone-generating part and control unit thereof, supplies ozone through air circulating fan, makes air flow by separate fan, and supplies hydrogen peroxide or limonene solution provided in cartridge type and vaporized. Air path is designed such that flow of ozone and flow of air of hydrogen peroxide or limonene solution are designed to maintain laminar flow state for smooth supply of the generated particles, turbulence inducing path for making turbulence easier when two streams meet each other is provided, separate air mixing space is created to create turbulent flow so that ozone and hydrogen peroxide, or ozone and limonene solution generate sufficient chemical reaction in this space to make OH radicals, and laminar flow path for spreading radicals or negative ions is provided, thereby sterilizing and purifying bacterial or indoor air suspended in air by the same principle as in the natural world.

The disclosed technology includes a system for sanitizing a user's hands or other objects using atomized water. The system can include a heating element for heating air, a blower for directing the heated air toward a user's hands or other objects, and one or more reservoirs for holding fluids, such as water and a sanitizing agent. The system can include an atomizing device for atomizing at least some of the fluid. The system can include a controller for controlling the various components of the system.

According to one implementation a central venous catheter is provided that includes an end emitting optical fiber that is configured to end emit bacterial disinfecting light to disinfect a conduit located inside the hub, the conduit connecting the working lumen of an infusion shaft with a working lumen of a main shaft.

A device and process to inactivate viruses and kill living bacteria using the available techniques like UV irradiation, heat, filtration, and/or chemical treatment, individually or all at once to achieve the best results. The operation of the invention could be programmed/controlled using a remote controller/programmer. The invention could be used in spaces occupied by humans or when humans are not present. When humans are not present it uses mainly UV irradiation, and when humans are present it circulates the air to be disinfected through a protective enclosure. In some applications using UV disinfection, the device can circulate and disinfect the air inside it, while irradiating the UV irradiations to other parts of the space to disinfect them. One embodiment of the device is similar to a mask, not just to collect the viruses and bacteria, but also, to inactivate the viruses and kill the bacteria. The invention will make indoor places very safe and safer than outdoors, because the indoor could be disinfected as a controlled enclosed space, while the outdoor is practically impossible to disinfect. Which will allow people to live better life without fears of contracting or spreading the viruses now or in the future. The invention is easy to install, operate, maintain, clean, and highly effective.

A multi-chamber package is described including a first and second chamber, the first chamber having a bottom wall and sidewalls defining a cavity, the second chamber having a partially open bottom wall and sidewalls defining a cavity. A first removable seal is positioned over a top surface of the package, fully covering the first chamber and second chamber, and a second seal is positioned over a bottom surface of the partially open floor of the second chamber, fully sealing the second chamber. A method of packaging medical devices is also described.