A prosthesis that contains zirconia and supplements a defective portion of a natural bone, and that is changed to a color approximate to that of the natural bone by a heat treatment after a γ-ray sterilization treatment. The color approximate to that of the natural bone has an L* value of 60 to 90, an a* value of −5 to 10, and a b* value of −5 to 10 in the L*a*b* color space. The highest temperature in the heat treatment is 100° C. to 300° C. The prosthesis is a fixture of a dental implant embedded into and bonded to a natural bone, an abutment, an implant crown, and the like.

A method is disclosed for producing a sterilized medical formed article that includes applying high-energy rays to a medical formed article at an exposure E. The medical formed article is formed of a resin composition that includes a hydrogenated block copolymer and a phenol-based antioxidant. The hydrogenated block copolymer is obtained by hydrogenating 99% or more of unsaturated bonds of a block copolymer that includes at least two polymer blocks [A] and at least one polymer block [B], the polymer block [A] including a repeating unit derived from an aromatic vinyl compound as a main component, the polymer block [B] including a repeating unit derived from a linear conjugated diene compound as a main component, and a ratio (wA:wB) of a weight fraction wA of the polymer block [A] to a weight fraction wB of the polymer block [B] being 30:70 to 70:30.

A field generator for use in a surgical targeting system is disclosed. The field generator includes a mounting structure including elements that are configured to receive components of an electromagnetic field generator. The elements are disposed on the mounting structure at locations and orientations relative to each other. The field generator includes at least one covering formed over the mounting structure, wherein, in use, the locations and orientations of the elements relative to each other remain substantially unaltered after exposure to one or more sterilization processes.

Method for sterilising a body fluid drainage system for handling a body fluid ex vivo. The body fluid drainage system comprises a chamber. The method comprises the steps providing a container containing a surface protective fluid to be released into the chamber of the body fluid drainage system, subjecting the container to radiation sterilisation, inserting the container into the chamber of the body fluid drainage system, and subjecting the chamber containing the container to gas sterilisation. A body fluid drainage system for handling a body fluid ex vivo. The body fluid drainage system comprises a chamber. The body fluid drainage system further comprises a container containing a surface protective fluid. The container is arranged to release the surface protective fluid into the chamber. The surface protective fluid is sterilised by radiation sterilisation. An outer surface of the container and at least the chamber of the body fluid drainage system is sterilised by gas sterilisation.

Ready to use packaged medical products that include hydrated hydrophilic medical devices and methods of making the same.

The present invention is directed to a polymer composition (C) comprising a first propylene homopolymer (H-PP), at least one hydrocarbon oil, at least one nucleating agent and at least one antioxidant, a moulded article formed from said polymer composition, a process for gamma-ray sterilization of said moulded article and uses of hydrocarbon oil in said polymer composition for improving resistance to gamma-ray radiation and reducing discoloration after gamma-ray sterilization in said polymer composition.

A spray dispenser is provided, the spray dispenser comprising a container for holding a liquid to be dispensed and a dispensing assembly for extracting liquid from said container, the dispensing assembly comprising a pressure-relief valve for release of excessive pressure in the container and a filter arranged to permit egress of gas through the filter, inhibit egress of liquid from the container and to inhibit ingress of contaminants into the container through the pressure relief valve. A dispensing assembly for use is a spray dispenser is also provided.

Terminally sterilized demineralized bone material (DBM) and systems and methods for protecting DBM against damage caused by terminal irradiation are described. A method includes providing the DBM, which includes at least a collagen matrix and natural, non-collagenous protein. The DBM is soaked in a mixture of glycerol and a solvent to remove and replace water in the collagen matrix of the DBM. The DBM is dried, after soaking, to form a protected DBM.

To provide an endoscope cap with a raising base or the like which is easily attached and detached to and from a distal end of an endoscope.

The endoscope cap includes: a cover that is attachable and detachable to and from a distal end of an insertion portion of an endoscope including a lever which is rotatably provided at the distal end of the insertion portion of the endoscope and a rotating portion which rotates the lever; and a raising base that has a lever connection portion connected to the lever and is rotatably provided inside the cover, and the endoscope cap is supplied in the state of being enclosed in an individual packaging member.

Provided herein are methods of reducing bioburden of a chromatography resin that include exposing a container including a composition including (i) a chromatography resin and (ii) a liquid including at least on alcohol to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one alcohol are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and a liquid including at least one alcohol, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.