The present invention concerns packaging for preserving a sterile pharmaceutical composition, comprising at least an inner layer of polypropylene having a thickness of between 200 and 800 μm and an outer layer made from polyethylene, the outer layer being in contact with the environment and having a thickness of between 300 and 1000 μm. The invention also concerns a method for the sterile preservation of a pharmaceutical composition using such packaging.

The present disclosure provides a surgical instrument including an end effector, a drive member movable to effectuate a motion in said end effector, a motor operable to move the drive member to effectuate the motion in the end effector and a bailout assembly operable to perform a mechanical bailout of the surgical instrument in response to a bailout error. The bailout assembly includes a bailout door, a bailout handle accessible through the bailout door. The bailout handle is operable to move the drive member to effectuate a bailout motion in the end effector. A controller includes a memory and a processor coupled to the memory. The processor is configured to detect the bailout error. The processor is programed to stop the motor in response to the detection of the bailout error.

The present disclosure provides a surgical instrument including an end effector, a drive member movable to effectuate a motion in said end effector, a motor operable to move the drive member to effectuate the motion in the end effector and a bailout assembly operable to perform a mechanical bailout of the surgical instrument in response to a bailout error. The bailout assembly includes a bailout door, a bailout handle accessible through the bailout door. The bailout handle is operable to move the drive member to effectuate a bailout motion in the end effector. A controller includes a memory and a processor coupled to the memory. The processor is configured to detect the bailout error. The processor is programed to stop the motor in response to the detection of the bailout error.

A system of managing the sterilisation of empty flexible pouches (1) provides applying sacrificial closures (200) to the empty pouches, loading the empty provisional closed pouches to be sterilised on a transport device (300) for the collective transportation, performing the sterilisation of the transport device (300) carrying the empty provisional closed pouches, and finally separating, in a sterile chamber, the sacrificial closures (200) from the pouches, filling and applying a tamper-proof cap (100).

The present invention deals with a new unimodal propylene-ethylene random copolymer providing improved resistance against gamma irradiation as well as compositions comprising the new unimodal propylene-ethylene random copolymer and final articles made therefrom.

A system for sterilizing sterilization units by radiation exposure comprises a conveyance system for transporting sterilization units through a sterilizing environment along a conveying path. The conveyance system comprises at least one lifting beam conveyor with at least one stationary supporting beam and at least one movable lifting beam, which is movable with respect to the at least one stationary supporting beam in a longitudinal and a vertical direction. The at least one stationary supporting beam has a central region between two fixed bearings, which is supported via at least one tensile-loaded tensile element, which is fastened to the central region and to at least one vertical strut, which is arranged in the region of at least one of the fixed bearings, in such a manner that the tensile element extends in a direction diagonal to the longitudinal and the vertical direction.

Methods and systems for removing gases and/or pressure formed during the sterilization, e.g., the gamma irradiation, of prepacked chromatography systems (column plus attached tube and valve set) are described. The methods include purging the gas and/or pressure through specially designed tube and valve sets without breaching the sterility of the prepacked sterile chromatography system. The systems include a sterile or aseptic pre-packed chromatography column including a column having an inlet and an outlet, a tubing and valve set attached to the inlet and the outlet, and a pump configured to pump sterile or aseptic liquid from the fluid source along the tubing and valve set, into the column tube inlet and out of the column tube outlet along a first flow path, thereby removing any entrapped gas and/or pressure from the chamber.

A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon dioxide depletion device to the storage vessel; and a gamma or X-ray irradiating device is used to irradiate red blood cells stored in the vessel, storing red blood cells under anaerobic conditions.

An ultraviolet cyclonic fluid dosing system for disinfecting fluid materials is described. The dosing system includes a dosing chamber that includes a cylindrical chamber portion and a conical chamber portion. The cylindrical chamber portion has a fluid outlet and a fluid inlet that causes fluid material to enter the upper chamber and travel a helical path down through the upper chamber and into the conical chamber, from where it travels upward in exits through the fluid outlet. As the fluid material passes through the cylindrical and conical chambers, it is dosed with disinfecting ultraviolet light. The system advantageously increases the exposure time of the fluid material to the disinfecting ultraviolet light is increased as compared to non-cyclonic dosing systems having the same volume.

A surgical instrument configured for use in a surgical procedure is disclosed herein. The surgical instrument comprises a housing, a first sensor configured to detect a condition of the surgical instrument, and a second sensor configured to detect the condition of the surgical instrument. The surgical instrument further comprises a processor, wherein the processor is located within the housing. The first sensor and the second sensor are in signal communication with the processor. The processor receives a first signal from the first sensor and a second signal from the second sensor. The processor is configured to utilize the first signal and the second signal to determine the condition and communicate instructions to the surgical instrument during the surgical procedure in view of the condition.