The present invention relates to an auto injector (1) comprising a prefilled liquid medicament container, a hollow auto injector body (2) housing the medicament container. The auto injector body (2) has an elongated part, a first end side (21) and a second end side (22) and at least one through hole (3) arranged between the end sides (21, 22). The through holes (3) allow for flow of gas through the auto injector body (2) when the auto injector body (2) houses the medicament container. The invention further relates to a method comprising inserting the auto injector (1) into the package via an opening in a non-inert environment, and, in a non-inert environment and under atmospheric pressure: replacing the air in the package with inert atmosphere by one or several cycles of removing air and inserting inert gas through the opening, wherein the air and inert gas in part flows through the at least one through hole (3) of the auto injector (1). The method further comprises sealing the opening under vacuum.

A sterilization challenge device for verifying the efficacy of a gas sterilization process includes an outer container, an inner container, a chemical indicator, and a cap. The outer container includes an open end, a closed end, a chamber configured to contain the inner container containing the chemical indicator, and at least one hole arranged proximate the open end. The cap is configured to engage with the outer container to close the open end, and the at least one hole is configured to provide a flow path for the gaseous sterilant into the chamber.

An example technique of forming a package includes retaining a package precursor in a support. The package precursor includes a shrink-formable composition and defines an interior volume configured to enclose a component, such as a medical supply. The package may be formed by at least directing a flow of heated medium from a nozzle toward at least one region of the package precursor to cause the at least one region to shrink faster than an adjacent region of the package precursor. In some examples, an example system for shrink-forming a package includes the support and the nozzle.

In some examples, a package includes a package body enclosing a medical supply. The package body defines a window. The package includes a breathable membrane adjacent the package body and extending across the window. The package includes a moisture oxygen scavenger adjacent the package body and extending across the breathable membrane. The package includes an adhesive layer configured to hold the moisture oxygen scavenger adjacent the breathable membrane. In some examples, a technique includes sterilizing a package precursor including the package body and the breathable membrane, and after the sterilizing, adhering the moisture oxygen scavenger to the package body to form the package.

Seal integrity indicators for sterilization containers are provided. For example, a seal indicator may indicate whether the container is sufficiently sealed to prevent an ingress of contaminants into the container. If the container is sufficiently sealed, the seal indicator is visible, but if not, the seal indicator is not visible. Thus, the seal indicator undergoes a change in state when the sterilization container transitions from unsealed to sealed, or vice versa, such that a user may ascertain whether the container is properly sealed to maintain the container's sterility. An exemplary seal indicator includes an invertible projection formed with the container gasket that is not visible from outside the container until inverted, due to force applied by the lid, to extend through an opening in the container body. Closure mechanisms for sterilization containers also are provided.

A surgical instrument is disclosed including a transducer configured to provide vibrations along a longitudinal axis, an end effector operably coupled to the transducer, and a stationary lower jaw extending parallel to the end effector. The end effector extends along the longitudinal axis. The end effector comprises a blade. The stationary lower jaw comprises a clamp face positioned distal to the blade. The end effector is movable relative to the stationary lower jaw to drive the blade distally towards the clamp face. The end effector comprises a hollow lumen. The end effector further comprises at least one member extended across a portion of the hollow lumen.

Syringe assemblies comprising a first cap and a second cap to ensure sterilization of the fluid path without the need for external packaging are described. Also described are methods of sterilizing the fluid path of a syringe assembly.

A decontamination system, method, and sterilant kit for a device, such as a lumen device, is depicted. The decontamination system, in some embodiments, includes a device container, a wicking pad, and a sterilant fluid delivery device. The device container, such as a terminal package or a decontamination chamber, defines a device receiving area. The wicking pad is in fluid communication with the device receiving area. The sterilant fluid delivery device is in fluid communication with the wicking pad. The sterilant fluid delivery device is configured to wet the wicking pad with sterilant fluid. The wicking pad is configured to evaporate sterilant fluid into the device receiving area.

A method of sterilizing a prefilled syringe comprises assembling a syringe assembly and performing at least one ethylene oxide (EtO) sterilization procedure cycle. The assembling step includes inserting a tip cap at a first end of a plunger, filling a non-glass barrel with sterilization sensitive material at a second end of the barrel, and inserting the plunger into the barrel at a second end to seal the sterilization sensitive material within the barrel. The EtO sterilization procedure cycle comprises undergoing a preprocessing stage, a wash and conditioning stage, an EtO sterilization stage and a wash and post exposure stage. Upon completing the EtO sterilization procedure cycle, a resultant pH of the sterilization-sensitive material does not exceed an acceptable pH range as defined by the United States Pharmacopeia. The disclosure also discusses inserting an assembled prefilled syringe into a procedure tray prior to performing the EtO sterilization procedure cycle.

A device for production and use of a disinfectant. The device may be used to disinfect materials or objects exposed to viruses and/or bacteria. In particular, the device is capable of converting at least one first reagent such as an alcohol and at least one second reagent including an oxidant into an active disinfectant agent. A catalytic system is incorporated into the reaction vessel to produce the active disinfectant as needed for the disinfection process.