The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc.

The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.

The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.

Disclosed is a medical device including a substrate and a polymer layer, wherein the polymer layer is provided on at least a part of a surface of the substrate and satisfies the following requirements: (a) a water content of the medical device in hydrated state is in a range of 28% by mass or more and 50% by mass or less; (b) the substrate has a 2-alkoxyethyl group; and (c) the polymer layer contains one type of a carboxylic acid group-containing polymer and one type of a copolymer having an amide structure. The present invention provides a medical device capable of maintaining surface wettability for a long time.

Disclosed is a medical device including a substrate and a polymer layer, wherein the polymer layer is provided on at least a part of a surface of the substrate and satisfies the following requirements: (a) a water content of the medical device in hydrated state is in a range of 28% by mass or more and 50% by mass or less; (b) the substrate has a 2-alkoxyethyl group; and (c) the polymer layer contains one type of a carboxylic acid group-containing polymer and one type of a copolymer having an amide structure. The present invention provides a medical device capable of maintaining surface wettability for a long time.

In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

Provided are a composite molding composition such as a composite film and a composite fiber that have properties such as an improved tensile strength, strain and toughness as a result of blending a peptide or polyamino acid having a β-sheet structure with a natural or artificially modified fibroin-derived protein; a method for producing such composite molding composition; and a method for improving the physical properties of a composite molding composition containing a fibroin-derived protein.

This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.

A hollow fiber that generally extends in a longitudinal direction is provided. The hollow fiber comprises a hollow cavity that extends along at least a portion of the fiber in the longitudinal direction. The cavity is defined by an interior wall that is formed front a thermoplastic composition containing a continuous phase that includes a polyolefin matrix polymer and a nanoinclusion additive dispersed within the continuous phase in the form of discrete domains. A porous network is defined in the composition that includes a plurality of nanopores.

A yarn, absorbent components and dressings comprising the yarn, and methods of treatment for wounds using said absorbent components and dressings are disclosed. The elastomeric yarn as disclosed herein comprises a yarn core fibre and a secondary fibre disposed exteriorly around the yarn core fibre. The yarn core fibre comprises an elastomeric material, and the secondary fibre is disposed exteriorly around the yarn core fibre. The secondary fibre comprises a superabsorbent material and/or a gelling material.