Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

A composition, comprising a hydrogel matrix and microparticles within said matrix, said matrix comprising a cross-linkable protein and a cross-linking agent, wherein said cross-linking agent is able to cross-link said cross-linkable protein, wherein said microparticles comprise a drug.

A composition, comprising a hydrogel matrix and microparticles within said matrix, said matrix comprising a cross-linkable protein and a cross-linking agent, wherein said cross-linking agent is able to cross-link said cross-linkable protein, wherein said microparticles comprise a drug.

A method for preparing a cell membrane-coated nano topological array and a use thereof are disclosed. The method includes: stimulating macrophages to form stimulated macrophages, and extracting the membrane of the stimulated macrophages; at the same time, processing a substrate to form a substrate with nanowires, and treating the substrate with nanowires to form a positively charged nanowire substrate; combining the membrane of the stimulated macrophages with the positively charged nanowire substrate to obtain a macrophage membrane-modified nano topological array. The present invention is simple in preparation and operation, and can be applied to capture bacteria.

A method for preparing a cell membrane-coated nano topological array and a use thereof are disclosed. The method includes: stimulating macrophages to form stimulated macrophages, and extracting the membrane of the stimulated macrophages; at the same time, processing a substrate to form a substrate with nanowires, and treating the substrate with nanowires to form a positively charged nanowire substrate; combining the membrane of the stimulated macrophages with the positively charged nanowire substrate to obtain a macrophage membrane-modified nano topological array. The present invention is simple in preparation and operation, and can be applied to capture bacteria.

The present invention relates to a polyurethane composition with antimicrobial properties, a polyurethane foam or coating comprising said polyurethane composition, an article prepared from said composition, foam or coating, a process for the preparation of said composition, the use of a complexing agent and an antimicrobial agent for the preparation of said composition or for imparting antimicrobial properties to a polyurethane composition, and a kit of components for preparing said composition. A cooperative effect is observed when specific complexing agents are combined with specific organic antimicrobially active components within the polyurethane composition.

The present invention relates to a polyurethane composition with antimicrobial properties, a polyurethane foam or coating comprising said polyurethane composition, an article prepared from said composition, foam or coating, a process for the preparation of said composition, the use of a complexing agent and an antimicrobial agent for the preparation of said composition or for imparting antimicrobial properties to a polyurethane composition, and a kit of components for preparing said composition. A cooperative effect is observed when specific complexing agents are combined with specific organic antimicrobially active components within the polyurethane composition.

Provided herein are compositions including polymeric binder or a salt thereof, high molecular weight polymer, pharmaceutically active agent and a low molecular weight cross-linking agent, methods for using the compositions to coat a substrate, and methods for making the compositions. Alternatively, the composition may include a polymeric binder or a salt thereof, high molecular weight polymer and a pharmaceutically active agent. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and/or protein binding.

Provided herein are compositions including polymeric binder or a salt thereof, high molecular weight polymer, pharmaceutically active agent and a low molecular weight cross-linking agent, methods for using the compositions to coat a substrate, and methods for making the compositions. Alternatively, the composition may include a polymeric binder or a salt thereof, high molecular weight polymer and a pharmaceutically active agent. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and/or protein binding.

Device comprising polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicator monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10
and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.