Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female.

A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female.

A wound covering is provided that comprises a substrate and vitamin D, or analogues or metabolites thereof, embedded in the substrate. Methods of making a wound covering are also provided and include the steps of providing a solution that includes a polymer; adding vitamin D, or analogues or metabolites thereof, to the solution to form a mixture; and forming one or more fibers from the mixture that are then embedded with the vitamin D, or analogues or metabolites thereof. Methods of treating a subject are further provided and include the step of applying a wound covering including one or more fibers embedded with vitamin D, or analogues or metabolites thereof, to a site on a subject.

A wound covering is provided that comprises a substrate and vitamin D, or analogues or metabolites thereof, embedded in the substrate. Methods of making a wound covering are also provided and include the steps of providing a solution that includes a polymer; adding vitamin D, or analogues or metabolites thereof, to the solution to form a mixture; and forming one or more fibers from the mixture that are then embedded with the vitamin D, or analogues or metabolites thereof. Methods of treating a subject are further provided and include the step of applying a wound covering including one or more fibers embedded with vitamin D, or analogues or metabolites thereof, to a site on a subject.

A water permeability-imparting agent containing an alkylene oxide adduct (A) of a polyvalent active hydrogen compound represented by Formula (1):

R—[O(A.sup.1O).sub.m—(CH.sub.2CH.sub.2O).sub.n—H].sub.1   (1)

wherein R represents a residue, after removal of all active hydrogen, of the polyvalent active hydrogen compound; A.sup.1O represents a C2 to C4 alkyleneoxy group; m represents an average addition mole number of A.sup.1O and is a number of 4 to 50; n represents an average addition mole number of CH.sub.2CH.sub.2O; and 1 represents a valence and is an integer of 3 to 6, and an average addition mole number ratio between A.sup.1O and CH.sub.2CH.sub.2O in Formula (1), n/m, is 0 to 0.5.

A water permeability-imparting agent containing an alkylene oxide adduct (A) of a polyvalent active hydrogen compound represented by Formula (1):

R—[O(A.sup.1O).sub.m—(CH.sub.2CH.sub.2O).sub.n—H].sub.1   (1)

wherein R represents a residue, after removal of all active hydrogen, of the polyvalent active hydrogen compound; A.sup.1O represents a C2 to C4 alkyleneoxy group; m represents an average addition mole number of A.sup.1O and is a number of 4 to 50; n represents an average addition mole number of CH.sub.2CH.sub.2O; and 1 represents a valence and is an integer of 3 to 6, and an average addition mole number ratio between A.sup.1O and CH.sub.2CH.sub.2O in Formula (1), n/m, is 0 to 0.5.

A gel is provided which is the condensation reaction product of the following composition: (i) at least one condensation curable silyl terminated polymer having at least one hydrolysable and/or hydroxyl functional group(s) per molecule; (ii) a cross-linker selected from the group of a silicone, an organic polymer, a silane or a disilane molecule which contains at least two hydrolysable groups per molecule; and (iii) a condensation catalyst selected from the group of titanates, zirconates or tin (II). The molar ratio of hydroxyl and/or hydrolysable groups in polymer (i) to hydrolysable groups from component (ii) is between 0.5:1 and 1:1 using a monosilane cross-linker or 0.75:1 to 3:1 using disilanes, and the molar ratio of M-OR or tin (II) functions to the hydroxyl and/or hydrolysable group(s) in polymer (i) is comprised between 0.01:1 and 0.5:1, where M is titanium or zirconium. The composition, and uses for the gel are also disclosed.

A gel is provided which is the condensation reaction product of the following composition: (i) at least one condensation curable silyl terminated polymer having at least one hydrolysable and/or hydroxyl functional group(s) per molecule; (ii) a cross-linker selected from the group of a silicone, an organic polymer, a silane or a disilane molecule which contains at least two hydrolysable groups per molecule; and (iii) a condensation catalyst selected from the group of titanates, zirconates or tin (II). The molar ratio of hydroxyl and/or hydrolysable groups in polymer (i) to hydrolysable groups from component (ii) is between 0.5:1 and 1:1 using a monosilane cross-linker or 0.75:1 to 3:1 using disilanes, and the molar ratio of M-OR or tin (II) functions to the hydroxyl and/or hydrolysable group(s) in polymer (i) is comprised between 0.01:1 and 0.5:1, where M is titanium or zirconium. The composition, and uses for the gel are also disclosed.

An absorbent article having a liquid permeable topsheet, a liquid impermeable sheet, an absorbent core disposed between the topsheet and the backsheet, and a secondary topsheet disposed between the topsheet and the absorbent core is described. The secondary topsheet has a first layer and a second layer. The first layer is located between the topsheet and the second layer, and a mean pore size of the first layer is larger than a mean pore size of the topsheet.