The present invention includes the composition and manufacturing of a product to treat various types of infections, and disease ailments. The invention embodies a disposable absorbent or nonabsorbent article comprising an unbound/freely associating adsorbent porous carbonaceous material for the entrapment and/or treatment of pathogens and adverse biological by-products. The product form includes three dimensional carriers such as tampons, panty liners, incontinence pads, diapers, sanitary towels, swabs, cotton balls, pouches, and/or plugs, which contain adsorbent porous carbonaceous material that effectively reduces and/or eliminates adverse situations sourcing from pathogens and harmful biological by-products, including fungi, bacteria, viruses, and parasites. The article is used to treat yeast infections, vaginitis, sexually transmitted diseases, tooth infections, abscess, nail-bed and cuticle infections, and other ailments by way of internal insertion and/or completely covering of the body cavity, mucous membrane, and/or affected areas, creating a clear and direct path for contact with pathogens and adverse biological by-products.

A material web is disclosed. The material web includes a fiber layer having a first side and an opposing second side. The fiber layer has a plurality of fibers, each of which having an intimate admixture of a thermoplastic polymer, and a wax and/or oil, wherein at least some of the wax and/or oil is exposed at an outer surface of the fibers. A surface energy treatment is disposed on the first side and/or the second side of the fiber layer.

A material web is disclosed. The material web includes a fiber layer having a first side and an opposing second side. The fiber layer has a plurality of fibers, each of which having an intimate admixture of a thermoplastic polymer, and a wax and/or oil, wherein at least some of the wax and/or oil is exposed at an outer surface of the fibers. A surface energy treatment is disposed on the first side and/or the second side of the fiber layer.

The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.

The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.

Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition. In addition, in some embodiments, at least a portion of the fibrinogen and/or fibrin can chemically react (e.g., the fibrinogen can polymerize to form fibrin and/or the fibrin can cross-link) during application of the compressive force. Reaction and concentration can lead to the formation of a highly-concentrated, mechanically robust patch that can be handled relatively easily and provide good structural reinforcement at a wet site, such as a bleeding wound.

Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition. In addition, in some embodiments, at least a portion of the fibrinogen and/or fibrin can chemically react (e.g., the fibrinogen can polymerize to form fibrin and/or the fibrin can cross-link) during application of the compressive force. Reaction and concentration can lead to the formation of a highly-concentrated, mechanically robust patch that can be handled relatively easily and provide good structural reinforcement at a wet site, such as a bleeding wound.

An absorbent article that prevents back flow and that uses cotton fibers in the surface sheet. The absorbent article is an incontinence pad having at least a medium volume for absorbing at least 20 cc of urine. A surface sheet is formed by coating, with a water-repellent, a spunlace non-woven fabric comprising 100 wt % of cotton fibers. The skin-facing surface side is provided with: a plurality of protrusions that extend along the longitudinal direction of the incontinence pad and are formed with gaps therebetween in the widthwise direction; and a plurality of recesses that extend along the longitudinal direction of the incontinence pad and are formed between adjacent protrusions. The recesses are formed thinner than the protrusions. A plurality of openings, which penetrate the incontinence pad from the front to the rear thereof, is formed along the recesses in at least a section (H) corresponding to an excretory opening.

Method of applying a skin beneficial agent to an absorbent article including a topsheet layer having a body facing surface and a garment facing surface, the article having a longitudinal front portion, a longitudinal back portion and a crotch portion located between the front and the back portion. The method includes at least the step of printing, by means of an in-line synchronized print technique, a water based ink composition including a binder and a microencapsulated skin beneficial agent on the article, the skin beneficial agent being at least a partly hydrophobic or lipophilic substance or additive, and the microcapsule material being water-insoluble at 20? C.

Method of applying a skin beneficial agent to an absorbent article including a topsheet layer having a body facing surface and a garment facing surface, the article having a longitudinal front portion, a longitudinal back portion and a crotch portion located between the front and the back portion. The method includes at least the step of printing, by means of an in-line synchronized print technique, a water based ink composition including a binder and a microencapsulated skin beneficial agent on the article, the skin beneficial agent being at least a partly hydrophobic or lipophilic substance or additive, and the microcapsule material being water-insoluble at 20? C.