Dressings for treating a tissue site with negative pressure are disclosed, which may include a dressing having multiple layers and incorporating a material adapted to neutralize proteolytic enzymes. In one example embodiment, a dressing may include a first layer comprising a hydrophobic gel having a plurality of apertures. A material adapted to neutralize proteolytic enzymes may be applied to a surface of the first layer. The dressing may further include a second layer comprising a fenestrated film and coupled to the first layer. Additionally, the dressing may include a third layer comprising a manifold, which in some instances may be a polymeric foam. The dressing may further include a fourth layer comprising a polymer drape.

The present disclosure relates generally to wound dressing compositions that include a β-glucan which can stimulate an immunomodulatory effect on cells within a wound, increase the healing rate of a wound, and stimulate the healing of recalcitrant wounds. The wound dressing includes a mixture of a collagen, a polysaccharide, and a β-glucan. Also disclosed herein are methods for use of the wound dressing as well as kits including the wound dressings of the present technology.

The present disclosure relates generally to wound dressing compositions that include a β-glucan which can stimulate an immunomodulatory effect on cells within a wound, increase the healing rate of a wound, and stimulate the healing of recalcitrant wounds. The wound dressing includes a mixture of a collagen, a polysaccharide, and a β-glucan. Also disclosed herein are methods for use of the wound dressing as well as kits including the wound dressings of the present technology.

The invention provides a constituent that is used with a novel method for preventing and/or treating skin wounds and ensures stable delivery of low-concentration hydrogen sulfide to a wound site. The skin wound-preventing and/or treating constituent includes a sustained hydrogen sulfide releasing agent that is preferably a layered double hydroxide having HS— and/or Sk2- between layers where k is a positive integer.

Described herein are electrospun core-shell fibers that include (i) a central core that is electrically conductive having an exterior surface, wherein the core comprises a first polymer and an electroconductive material; (ii) a shell adjacent to the exterior surface of the core, the shell comprising a second polymer; and (iii) one or more bioactive agents in the shell. In one aspect, the fibers are electrospun fibers. Additionally, described herein are methods for making and using the core-shell fibers.

The invention relates to an antiseptic material, in particular as a wound dressing, containing a carrier material and at least one antiseptic together with a surfactant, wherein the carrier material is equipped with a cyclodextrin or cyclodextrin derivative that is loaded in the antiseptic or antiseptics.

The invention relates to an antiseptic material, in particular as a wound dressing, containing a carrier material and at least one antiseptic together with a surfactant, wherein the carrier material is equipped with a cyclodextrin or cyclodextrin derivative that is loaded in the antiseptic or antiseptics.

An article having anti-microbial effect is provided. The article includes an occlusive layer and a substrate having a nanostructured surface. The nanostructured surface is coated with a metal oxide layer and the metal oxide layer includes a metal oxide.

An article having anti-microbial effect is provided. The article includes an occlusive layer and a substrate having a nanostructured surface. The nanostructured surface is coated with a metal oxide layer and the metal oxide layer includes a metal oxide.

The present technology generally relates to a biomaterial that includes a thiolated biopolymer and one or more agents that include growth factors, peptides, or combinations thereof, where the one or more agents are conjugated to the thiolated biopolymer. Also disclosed herein are wound dressings that include the biomaterial of the present technology, methods of treating a wound upon application of the wound dressing, and kits including the wound dressing and instructions for use.