The present disclosure provides wound dressing compositions that disrupt biofilm formation in a wound upon application. The wound dressing composition includes a first layer comprising a homogeneous mixture of a collagen, an oxidized regenerated cellulose (ORC), and at least one bacteria reducing active ingredient and a second layer comprising a homogeneous mixture of a collagen, an oxidized regenerated cellulose (ORC), a silver compound, and at least one bacteria reducing active ingredient, and the uses thereof. Also disclosed herein are kits comprising the wound dressing compositions of the present technology, and instructions for use.

Interpenetrating network hydrogels with independently tunable stiffness enhance tissue regeneration and wound healing.

Interpenetrating network hydrogels with independently tunable stiffness enhance tissue regeneration and wound healing.

A swellable polymer based fibre and method of preparing the same for use as, for example, a wound dressing. The fibres may be formed from an aqueous dope solution containing a primary polymer and povidone-iodine (PVP-I). The aqueous dope solution is spun or extruded into a coagulation bath via a multi-hole spinneret head to form a multifilament fibre.

A swellable polymer based fibre and method of preparing the same for use as, for example, a wound dressing. The fibres may be formed from an aqueous dope solution containing a primary polymer and povidone-iodine (PVP-I). The aqueous dope solution is spun or extruded into a coagulation bath via a multi-hole spinneret head to form a multifilament fibre.

The invention concerns a composition to be electrospun comprising a first compound to be electrospun, an electrospinning promoter and at least one active ingredient, as well as a method to prepare it. This composition allows to obtain electrospun nanometric fibers with good structural and absorption properties.

A method of promoting wound healing in a patient, the method comprising applying on a wound a biodegradable amino-acid based polymer.

In various exemplary embodiments, the present disclosure provides organohydrogel fibers and a process for making the organohydrogel fibers. The organohydrogel fibers have a hydrophobic phase dispersed in a hydrophilic phase. The organohydrogel fibers contain at least one hydrophobic active pharmaceutical ingredient (API), and at least one hydrophilic API. The organohydrogel fibers can be formed into a non-woven or 3D printed patch and a replaceable backing can be attached to the patch to make an effective wound dressing. The wound dressing can deliver active pharmaceutical ingredients to the wound over a period of multiple days.

In various exemplary embodiments, the present disclosure provides organohydrogel fibers and a process for making the organohydrogel fibers. The organohydrogel fibers have a hydrophobic phase dispersed in a hydrophilic phase. The organohydrogel fibers contain at least one hydrophobic active pharmaceutical ingredient (API), and at least one hydrophilic API. The organohydrogel fibers can be formed into a non-woven or 3D printed patch and a replaceable backing can be attached to the patch to make an effective wound dressing. The wound dressing can deliver active pharmaceutical ingredients to the wound over a period of multiple days.

The present invention provides a hemostatic porous composite sponge comprising: i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.