Glucocorticoid-induced leucine zipper protein (GILZ) peptide compositions and their methods of use in wound healing are disclosed herein. An exemplary GILZ peptide composition includes a GILZ fusion protein. The GILZ peptide compositions can be administered topically to wounds, for example in the form of a cream, ointment, or lotion. The GILZ peptide compositions can be used to treat acute wounds, induce wound healing in chronic wounds, and reduce scar formation.

Methods of treating a fungal infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising one or more antifungal peptides selected from the group consisting of BmKn2, dBmKn2, Kn2-7, and dKn2-7 are described. Antifungal pharmaceutical compositions and dosage forms, including field-deployable dosage forms, comprising one or more of these antifungal peptides are also described.

Methods of treating a fungal infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising one or more antifungal peptides selected from the group consisting of BmKn2, dBmKn2, Kn2-7, and dKn2-7 are described. Antifungal pharmaceutical compositions and dosage forms, including field-deployable dosage forms, comprising one or more of these antifungal peptides are also described.

The present disclosure provides for oxygen generating and free radical scavenging biomaterials, an article including the oxygen generating and free radical scavenging biomaterial, wound healing dressings or structures (e.g., bandage) that have the characteristic of generating oxygen and having redox modulating capabilities. In particular, the wound healing dressing can have the characteristics of being anti-inflammatory, antioxidant, and pro-healing for extended periods of time (e.g., at least 10 days, at least 30 days).

The present disclosure provides for oxygen generating and free radical scavenging biomaterials, an article including the oxygen generating and free radical scavenging biomaterial, wound healing dressings or structures (e.g., bandage) that have the characteristic of generating oxygen and having redox modulating capabilities. In particular, the wound healing dressing can have the characteristics of being anti-inflammatory, antioxidant, and pro-healing for extended periods of time (e.g., at least 10 days, at least 30 days).

Disclosed herein are matrices, compositions and methods of making matrices. The matrix comprises a biomolecule and the matrix is a dried, cross-linked foam. The matrix is not lyophilized. The method comprises foaming the composition, crosslinking the composition and drying the composition. Matrices disclosed herein are useful as wound dressings and treating wounds.

Disclosed herein are matrices, compositions and methods of making matrices. The matrix comprises a biomolecule and the matrix is a dried, cross-linked foam. The matrix is not lyophilized. The method comprises foaming the composition, crosslinking the composition and drying the composition. Matrices disclosed herein are useful as wound dressings and treating wounds.

A hemostatic material is described, which eliminates the risks of conventional chitosan-derived products, such as the onset of shellfish allergy and endotoxin contamination, can be used safely for more people, and has an antibacterial property and a hemostatic function that widely-used hydrogels lack, and a wound dressing containing the same. A hemostatic material containing cationized cellulose and a wound dressing containing the hemostatic are described. At least one of hydroxyl groups of the cationized cellulose is modified with —R.sup.2—N.sup.+(R.sup.3)(R.sup.4)(R.sup.5)X.sup.−, other hydroxyl groups of the cationized cellulose have —H, or —(CH.sub.2CH.sub.2O).sub.m—H, R.sup.2 represents C.sub.1-6 alkylene, C.sub.2-6 hydroxyalkylene, —(CH.sub.2CH.sub.2O).sub.1—, or a combination thereof, 1 represents 1 or 2, m represents 1 or 2, and X.sup.− may represent an anionic group.

A hemostatic material is described, which eliminates the risks of conventional chitosan-derived products, such as the onset of shellfish allergy and endotoxin contamination, can be used safely for more people, and has an antibacterial property and a hemostatic function that widely-used hydrogels lack, and a wound dressing containing the same. A hemostatic material containing cationized cellulose and a wound dressing containing the hemostatic are described. At least one of hydroxyl groups of the cationized cellulose is modified with —R.sup.2—N.sup.+(R.sup.3)(R.sup.4)(R.sup.5)X.sup.−, other hydroxyl groups of the cationized cellulose have —H, or —(CH.sub.2CH.sub.2O).sub.m—H, R.sup.2 represents C.sub.1-6 alkylene, C.sub.2-6 hydroxyalkylene, —(CH.sub.2CH.sub.2O).sub.1—, or a combination thereof, 1 represents 1 or 2, m represents 1 or 2, and X.sup.− may represent an anionic group.

Embodiments of the present disclosure relate to a violacein-polymer composite nanofibrous antimicrobial membrane and a method for manufacturing same, wherein the membrane comprises violacein having antimicrobial efficacy against methicillin-resistant Staphylococcus aureus (MRSA) caused by resistance to antibiotics and is formed such that one-dimensional nanofibers are three-dimensionally entangled, and can be used as an antimicrobial membrane for preventing and treating MRSA infections. Specifically, a solution in which violacein is uniformly mixed is prepared by dissolving a large amount of violacein in a solution with a polymer dissolved therein, and the solution is subjected to an electrospinning process to synthesize a nanofibrous membrane in which violacein is uniformly included inside/outside nanofibers without agglomeration. Thus, this is different from existing methods for applying a material to the surface of fibers.