A medical dressing (30) is disclosed, comprising an adhesive layer (3) having a skin-facing surface (6) to adhere the medical dressing to a dermal surface, wherein said adhesive layer comprises a first chemical compound incorporated within said adhesive layer, and wherein at least a portion of said skin-facing surface comprises a coating (9) comprising a second chemical compound. Also disclosed is a method of manufacturing such a medical dressing.

A medical dressing is disclosed, comprising a substrate comprising a first chemical compound, said substrate having a first surface, wherein said medical dressing further comprises an adhesive layer having a skin-facing surface to adhere said medical dressing to a dermal surface, wherein at least a portion of said skin-facing surface comprises a coating comprising a second chemical compound. Also disclosed is a method of manufacturing such a medical dressing.

The present disclosure comprises antimicrobial compositions and devices comprising silver compounds that resist heat and light discoloration. In one aspect, the said compounds comprise silver and at least one s-triazine ring or moiety. In another aspect, the antimicrobial compositions are hydrogels that are effective against broad spectrum of common pathogens including MRSA and VRE and are suitable for treating human or animal wounds and burns. The methods of the present disclosure comprise treating medical and non-medical devices and articles with compositions comprising the silver compounds to impart antimicrobial property.

The present disclosure comprises antimicrobial compositions and devices comprising silver compounds that resist heat and light discoloration. In one aspect, the said compounds comprise silver and at least one s-triazine ring or moiety. In another aspect, the antimicrobial compositions are hydrogels that are effective against broad spectrum of common pathogens including MRSA and VRE and are suitable for treating human or animal wounds and burns. The methods of the present disclosure comprise treating medical and non-medical devices and articles with compositions comprising the silver compounds to impart antimicrobial property.

Methods are provided for treatment of wounds using a complex antimicrobial sorption composition possessing the necrolytic effect for treating the purulent wounds, the trophic ulcers, the wounds, and the infiltrates with the significant necrotic and exudative components represents the silica sorbent with the immobilized drug. Pyrogenic silica is used as a siliceous sorbent, and serrathiopeptidase as a drug.

Methods are provided for treatment of wounds using a complex antimicrobial sorption composition possessing the necrolytic effect for treating the purulent wounds, the trophic ulcers, the wounds, and the infiltrates with the significant necrotic and exudative components represents the silica sorbent with the immobilized drug. Pyrogenic silica is used as a siliceous sorbent, and serrathiopeptidase as a drug.

Provided herein are a biocompatible hemostatic product and a tissue sealant, including polyethylene oxide particles with a viscosity-average molecular weight ranging from 100,000 to 7,000,000 Daltons, a particle size ranging from 0.5 μm to 2000 μm and a water absorbency capacity ranging from 1 to 500 times of its own weight. Also provided herein is a method for preparing biocompatible hemostatic product and tissue sealant and the use of the biocompatible hemostatic product and tissue sealant in hemostasis, preventing adhesion, avoiding infection, promoting tissue healing, and sealing wound of tissues and organs either on animal's body surface, or inside body's cavity.

Aspects of the present disclosure relate to an article that includes a conformable backing having first and second opposed major surfaces. The conformable backing can be formed from a thermoplastic polymer selected from a group consisting of polyurethanes, polyesters, and combinations thereof. The conformable backing has a tensile strength of no greater than 60 grams per centimeter force at 25% elongation in a machine direction according to the Tensile and Elongation Test Method. A hydrophobic adhesive can be disposed on a portion of the first major surface of the conformable backing. The hydrophobic adhesive includes a cationic, bioactive agent, a hydrophobic solubilizer capable of solubilizing at least part of the bioactive agent, and a hydrophobic plasticizing agent having a weight average molecular weight of above 1500.

Aspects of the present disclosure relate to an article that includes a conformable backing having first and second opposed major surfaces. The conformable backing can be formed from a thermoplastic polymer selected from a group consisting of polyurethanes, polyesters, and combinations thereof. The conformable backing has a tensile strength of no greater than 60 grams per centimeter force at 25% elongation in a machine direction according to the Tensile and Elongation Test Method. A hydrophobic adhesive can be disposed on a portion of the first major surface of the conformable backing. The hydrophobic adhesive includes a cationic, bioactive agent, a hydrophobic solubilizer capable of solubilizing at least part of the bioactive agent, and a hydrophobic plasticizing agent having a weight average molecular weight of above 1500.

Methods, processes and compositions are provided for improved wound dressings comprising an antimicrobial composition. The wound dressings maintain conformability and strength, as well as antimicrobial performance, upon use after storage.