Interpenetrating network hydrogels with independently tunable stiffness enhance tissue regeneration and wound healing.

Interpenetrating network hydrogels with independently tunable stiffness enhance tissue regeneration and wound healing.

Provided are both a superabsorbent polymer capable of continuously and safely exhibiting an improved bacterial growth inhibitory property and a deodorant property without deterioration in the physical properties of the superabsorbent polymer, such as water retention capacity, absorption under pressure, etc., as well as a preparation method for the superabsorbent polymer.

Provided are both a superabsorbent polymer capable of continuously and safely exhibiting an improved bacterial growth inhibitory property and a deodorant property without deterioration in the physical properties of the superabsorbent polymer, such as water retention capacity, absorption under pressure, etc., as well as a preparation method for the superabsorbent polymer.

An AM/AV material, comprising a topsheet layer comprising fibers comprising a topsheet polymer composition, a backsheet layer comprising fibers comprising a backsheet polymer composition; and an absorbent core configured therebetween, wherein the fibers of at least one of the layers, e.g., the topsheet layer, comprise an AM/AV compound, and wherein the fibers of the topsheet layer demonstrate a rewet value less than 5 g after a first water application and/or a Staph aureus efficacy log reduction greater than 2.6, as measured in accordance with ISO 20743:2013.

An AM/AV material, comprising a topsheet layer comprising fibers comprising a topsheet polymer composition, a backsheet layer comprising fibers comprising a backsheet polymer composition; and an absorbent core configured therebetween, wherein the fibers of at least one of the layers, e.g., the topsheet layer, comprise an AM/AV compound, and wherein the fibers of the topsheet layer demonstrate a rewet value less than 5 g after a first water application and/or a Staph aureus efficacy log reduction greater than 2.6, as measured in accordance with ISO 20743:2013.

In various exemplary embodiments, the present disclosure provides organohydrogel fibers and a process for making the organohydrogel fibers. The organohydrogel fibers have a hydrophobic phase dispersed in a hydrophilic phase. The organohydrogel fibers contain at least one hydrophobic active pharmaceutical ingredient (API), and at least one hydrophilic API. The organohydrogel fibers can be formed into a non-woven or 3D printed patch and a replaceable backing can be attached to the patch to make an effective wound dressing. The wound dressing can deliver active pharmaceutical ingredients to the wound over a period of multiple days.

A composition, comprising a hydrogel matrix and microparticles within said matrix, said matrix comprising a cross-linkable protein and a cross-linking agent, wherein said cross-linking agent is able to cross-link said cross-linkable protein, wherein said microparticles comprise a drug.

A method for preparing a cell membrane-coated nano topological array and a use thereof are disclosed. The method includes: stimulating macrophages to form stimulated macrophages, and extracting the membrane of the stimulated macrophages; at the same time, processing a substrate to form a substrate with nanowires, and treating the substrate with nanowires to form a positively charged nanowire substrate; combining the membrane of the stimulated macrophages with the positively charged nanowire substrate to obtain a macrophage membrane-modified nano topological array. The present invention is simple in preparation and operation, and can be applied to capture bacteria.

Provided herein are compositions including polymeric binder or a salt thereof, high molecular weight polymer, pharmaceutically active agent and a low molecular weight cross-linking agent, methods for using the compositions to coat a substrate, and methods for making the compositions. Alternatively, the composition may include a polymeric binder or a salt thereof, high molecular weight polymer and a pharmaceutically active agent. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and/or protein binding.