Hemostatic compositions including a combination of more than one hemostatic agent, and devices coated or impregnated therewith, have been developed. Nanotechnology yields hemostatic agents with large surface areas thereof, thereby increasing the hemostatic properties of the device to which they are applied. By combining more than one hemostatic agent and utilizing one or more different nanotechnology approaches to enhance the surface areas thereof, the capability of the dressing to stop bleeding is improved via more than one mechanism, and thus provides better hemostasis.

The present invention relates to a hydrophilic foam material, which is of particular use in wound treatment, and to a method for producing said hydrophilic foam material. The hydrophilic foam material has nucleating particles, wherein at least 85% of all foam cells in said foam material have an average cell size of 0.01 mm.sup.2 or less.

The present invention relates to a hydrophilic foam material, which is of particular use in wound treatment, and to a method for producing said hydrophilic foam material. The hydrophilic foam material has nucleating particles, wherein at least 85% of all foam cells in said foam material have an average cell size of 0.01 mm.sup.2 or less.

The present disclosure relates to a film for oral hemostasis and wound protection and, more particularly, to a film for oral hemostasis and wound protection which, being attached to a wound area in an oral cavity, delays or prevents microbleeds and controls medicinal component release. The film provided by the present disclosure is capable of including a polyol, an alcohol and a biodegradable polymer in the state of partial swelling, thereby locally absorbing blood or pus or arresting hemorrhage. Moreover, due to its high elongation ratio, the film provided by the present disclosure is capable of maintaining its adhesive force even when having blood, saliva and pus absorbed inside an oral cavity and conveniently deforming according to the shape of a seriously corrugated local area, which causes only slight foreign body sensation even after a long period of time of attachment on to the local area. In addition, the film provided by the present disclosure includes a disintegrant which is dissolved and released by reacting with blood to form microchannels that act as paths for drug release and is capable of adjusting the amount and the size of the microchannels, thereby controlling the amount of drug release. The present disclosure doesn't require a patient to detach the film attached inside an oral cavity by hand because the adhesive layer and the backing layer dissolve entirely over time.

The present disclosure relates to a film for oral hemostasis and wound protection and, more particularly, to a film for oral hemostasis and wound protection which, being attached to a wound area in an oral cavity, delays or prevents microbleeds and controls medicinal component release. The film provided by the present disclosure is capable of including a polyol, an alcohol and a biodegradable polymer in the state of partial swelling, thereby locally absorbing blood or pus or arresting hemorrhage. Moreover, due to its high elongation ratio, the film provided by the present disclosure is capable of maintaining its adhesive force even when having blood, saliva and pus absorbed inside an oral cavity and conveniently deforming according to the shape of a seriously corrugated local area, which causes only slight foreign body sensation even after a long period of time of attachment on to the local area. In addition, the film provided by the present disclosure includes a disintegrant which is dissolved and released by reacting with blood to form microchannels that act as paths for drug release and is capable of adjusting the amount and the size of the microchannels, thereby controlling the amount of drug release. The present disclosure doesn't require a patient to detach the film attached inside an oral cavity by hand because the adhesive layer and the backing layer dissolve entirely over time.

An absorbent article having a longitudinal centerline, a lateral centerline, a machine direction (MD) generally oriented parallel to the longitudinal centerline and a cross direction (CD) generally oriented parallel to the lateral centerline is described. The absorbent article includes a topsheet, a backsheet, and an absorbent core disposed therebetween. A plurality of composition elements is disposed on the topsheet, wherein each of the composition elements comprise an element width and an element spacing between adjacent elements, and wherein a ratio of element spacing to element width is between about 0.5 to about 8, as measured by the Composition Pattern Analysis.

An absorbent article includes a liquid-permeable top sheet, a liquid-impermeable back sheet, and an absorbent body between the liquid-permeable top sheet and liquid-impermeable back sheet. The liquid-permeable top sheet includes a blood modifying agent with an IOB of 0.00-0.60, a melting point of no higher than 45 C., a water solubility of 0.00-0.05 g in 100 g of water at 25 C., and a weight-average molecular weight of no greater than 1,000.

An absorbent article having a liquid pervious topsheet wherein at least a portion of the topsheet has been treated to become hydrophobic; a backsheet joined to said topsheet; an absorbent core disposed between said topsheet and said backsheet, said absorbent core having an inner surface oriented toward the skin of the wearer when said absorbent article is being worn and an outer surface oriented toward the garment of the wearer when said absorbent article is being worn; and a surfactant applied to at least a portion of said outer surface of said topsheet wherein the topsheet has been treated hydrophobic and wherein the hydrophilic surfactant is added to the areas treated hydrophobic.

An absorbent article having a liquid pervious topsheet wherein at least a portion of the topsheet has been treated to become hydrophobic; a backsheet joined to said topsheet; an absorbent core disposed between said topsheet and said backsheet, said absorbent core having an inner surface oriented toward the skin of the wearer when said absorbent article is being worn and an outer surface oriented toward the garment of the wearer when said absorbent article is being worn; and a surfactant applied to at least a portion of said outer surface of said topsheet wherein the topsheet has been treated hydrophobic and wherein the hydrophilic surfactant is added to the areas treated hydrophobic.

Antimicrobial dressings effective for treating biofilms in wounds are provided. One embodiment provides a wound dressing containing a silver-releasing conformable substrate and hydrogel containing a therapeutic substance. The hydrogel layer optionally may contain a pattern and/or one or more apertures, and may be secured by an optional non-adherent netting. A preferred substrate is a silver-coated substrate, for example silver-coated nylon. The silver-coated nylon can be a knitted, woven, compound, or complex fabric. Silver fibers can be combined within non-woven fabrics. The silver containing substrate, can be non-adherent and/or may contain one or more apertures, and/or may contain elastane. The dressing optionally contains one or more of: an adhesive layer, a separation layer, a moisture regulation layer, a film layer, and combinations thereof.