A method of producing a medical device having a substrate and a hydrophilic polymer layer, including the steps of: pretreating the substrate by placing the substrate in an alkali solution and heating the substrate at a temperature ranging from 50° C. to 100° C.; and heating a solution containing the pretreated substrate, a hydrophilic polymer having an acidic group and a hydroxyalkyl group, and an organic acid at a temperature ranging from 50° C. to 100° C. Provided is a simple method of producing a medical device imparted with hydrophilicity excellent in durability.

Natural honey and a surfactant are combined to achieve a novel wound treatment composition. The honey is chosen for its medicinal properties, and the surfactant is used for biofilm removal to enhance the effectiveness of the honey. In preferred embodiments, the honey is a tropical honey currently sourced from Mexico. The surfactant is mixed with water, then the aqueous mixture is combined with the honey. In accordance with a preferred embodiment, a surfactant powder is mixed with water at a ratio of 10% powder to water, then that mixture is combined with honey at a ratio greater than 50:50, more preferably at a ratio of 90:10. The currently preferred surfactant is Poloxamer 188. The product may be applied directly to a wound or applied to wound dressings including, without limitation, gauze, gauze rolls, hydrocolloids, and calcium alginate dressings.

A method of producing a medical device having a substrate and a hydrophilic polymer layer, including the steps of: pretreating the substrate by placing the substrate in an alkali solution and heating the substrate at a temperature ranging from 50° C. to 100° C.; and heating a solution containing the pretreated substrate, a hydrophilic polymer having an acidic group and a hydroxyalkyl group, and an organic acid at a temperature ranging from 50° C. to 100° C. Provided is a simple method of producing a medical device imparted with hydrophilicity excellent in durability.

Provided is a water-absorbing agent that causes no or little fluctuation of feed rate when fed with use of a feeder. A water-absorbing agent containing a water-absorbing resin as a main component, the water-absorbing agent satisfying the following (a) and (b): (a) K-index is 70 or more; and (b) Moisture absorption blocking ratio, after 30 minutes of standing at a temperature of 25° C. and a relative humidity of 80% RH, is 70 weight % or less, the K-index being defined by the following equation: K-index=100−(−438+3.6×angle of repose+3.5×angle of difference+7.9×compressibility rate+290×bulk density (EDANA method)).

In various exemplary embodiments, the present disclosure provides organohydrogel fibers and a process for making the organohydrogel fibers. The organohydrogel fibers have a hydrophobic phase dispersed in a hydrophilic phase. The organohydrogel fibers contain at least one hydrophobic active pharmaceutical ingredient (API), and at least one hydrophilic API. The organohydrogel fibers can be formed into a non-woven or 3D printed patch and a replaceable backing can be attached to the patch to make an effective wound dressing. The wound dressing can deliver active pharmaceutical ingredients to the wound over a period of multiple days.

In various exemplary embodiments, the present disclosure provides organohydrogel fibers and a process for making the organohydrogel fibers. The organohydrogel fibers have a hydrophobic phase dispersed in a hydrophilic phase. The organohydrogel fibers contain at least one hydrophobic active pharmaceutical ingredient (API), and at least one hydrophilic API. The organohydrogel fibers can be formed into a non-woven or 3D printed patch and a replaceable backing can be attached to the patch to make an effective wound dressing. The wound dressing can deliver active pharmaceutical ingredients to the wound over a period of multiple days.

The present invention provides absorbent materials comprising a hydrogel-forming swellable polymer and a plasticizer, wherein the absorbent material demonstrates an advantageous performance characteristic such as advantageous fluid absorption capacity, fluid absorption rate, and rewetting, wherein the advantageous performance characteristic is within at least about 80% of a similar characteristic exhibited by a crosslinked polyacrylate superabsorbent polymer, or wherein the cumulative performance of the advantageous performance characteristics is comparable or superior to performance exhibited by the crosslinked polyacrylate superabsorbent polymer. The present invention also relates to articles of manufacture comprising such absorbent materials, and methods of manufacture.

The present invention provides absorbent materials comprising a hydrogel-forming swellable polymer and a plasticizer, wherein the absorbent material demonstrates an advantageous performance characteristic such as advantageous fluid absorption capacity, fluid absorption rate, and rewetting, wherein the advantageous performance characteristic is within at least about 80% of a similar characteristic exhibited by a crosslinked polyacrylate superabsorbent polymer, or wherein the cumulative performance of the advantageous performance characteristics is comparable or superior to performance exhibited by the crosslinked polyacrylate superabsorbent polymer. The present invention also relates to articles of manufacture comprising such absorbent materials, and methods of manufacture.

The present invention relates to a wound dressing composition that is capable of gelling upon contact with a fluid derived from a human or animal body, and which is able to maintain the integrity of the gel for a period of time that is longer than about 24 hours.

The present invention relates to a wound dressing composition that is capable of gelling upon contact with a fluid derived from a human or animal body, and which is able to maintain the integrity of the gel for a period of time that is longer than about 24 hours.