Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

A composition comprising at least one polymer having the structure A-B-A′, wherein A and A′ may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and A and A′. Additionally, a bioresorbable patch comprising: (a) an adhesion barrier component comprising the composition in the form of a film; and (b) an adhesive component comprising (i) at least one synthetic adhesive polymer and/or (ii) at least one polysaccharide. Also, a method of wound healing, comprising administering the composition or apply the patch to a patient.

A composition comprising at least one polymer having the structure A-B-A′, wherein A and A′ may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and A and A′. Additionally, a bioresorbable patch comprising: (a) an adhesion barrier component comprising the composition in the form of a film; and (b) an adhesive component comprising (i) at least one synthetic adhesive polymer and/or (ii) at least one polysaccharide. Also, a method of wound healing, comprising administering the composition or apply the patch to a patient.

According to an illustrative embodiment, a system for treating a wound at a tissue site of a patient comprising a reduced-pressure source to supply reduced pressure, a drape adhering to the tissue site to cover the wound where possible leak passages between the drape and the tissue site may occur, and a seal disposed between the drape and the tissue site, is disclosed. The seal is adapted to react with a fluid to form a sealant substantially filling the passages in response to air leaking through the passages from outside the drape when reduced pressure is applied to the wound. According to another illustrative embodiment, a method for sealing a drape to a tissue site for treating a wound at the tissue site comprising applying the drape to cover the tissue site whereby passages are formed between the drape and the tissue site, positioning a seal between the drape and the tissue site wherein the seal is adapted to react with a fluid to form a sealant for substantially filling the passages, is also disclosed.

According to an illustrative embodiment, a system for treating a wound at a tissue site of a patient comprising a reduced-pressure source to supply reduced pressure, a drape adhering to the tissue site to cover the wound where possible leak passages between the drape and the tissue site may occur, and a seal disposed between the drape and the tissue site, is disclosed. The seal is adapted to react with a fluid to form a sealant substantially filling the passages in response to air leaking through the passages from outside the drape when reduced pressure is applied to the wound. According to another illustrative embodiment, a method for sealing a drape to a tissue site for treating a wound at the tissue site comprising applying the drape to cover the tissue site whereby passages are formed between the drape and the tissue site, positioning a seal between the drape and the tissue site wherein the seal is adapted to react with a fluid to form a sealant for substantially filling the passages, is also disclosed.

The present disclosure provides various cyanobacterial extracts exhibiting antiviral activity to a wide spectrum of viruses, such as enterovirus (EV), respiratory syncytial virus (RSV), Human Herpesvirus (HHV), Ebola virus, porcine epidemic diarrhea virus (PEDV), and porcine reproductive and respiratory syndrome virus (PRRSV). The cyanobacterial extract is prepared from biomass of A. maxima (or Spirulina maxima). Also disclosed herein are process for preparing the cyanobacterial extract and uses of the cyanobacterial extract.

The present disclosure provides various cyanobacterial extracts exhibiting antiviral activity to a wide spectrum of viruses, such as enterovirus (EV), respiratory syncytial virus (RSV), Human Herpesvirus (HHV), Ebola virus, porcine epidemic diarrhea virus (PEDV), and porcine reproductive and respiratory syndrome virus (PRRSV). The cyanobacterial extract is prepared from biomass of A. maxima (or Spirulina maxima). Also disclosed herein are process for preparing the cyanobacterial extract and uses of the cyanobacterial extract.

Provided are buffered adhesive compositions comprising a high molecular weight non-neutralized polymeric acid and a high molecular weight partially neutralized polymeric acid and products such as wound dressings and ostomy skin barriers incorporating the compositions.

A medical dressing (30) is disclosed, comprising an adhesive layer (3) having a skin-facing surface (6) to adhere the medical dressing to a dermal surface, wherein said adhesive layer comprises a first chemical compound incorporated within said adhesive layer, and wherein at least a portion of said skin-facing surface comprises a coating (9) comprising a second chemical compound. Also disclosed is a method of manufacturing such a medical dressing.

A medical dressing (30) is disclosed, comprising an adhesive layer (3) having a skin-facing surface (6) to adhere the medical dressing to a dermal surface, wherein said adhesive layer comprises a first chemical compound incorporated within said adhesive layer, and wherein at least a portion of said skin-facing surface comprises a coating (9) comprising a second chemical compound. Also disclosed is a method of manufacturing such a medical dressing.