A surgical implant (20) comprises a flexible basic structure (22) having a face and a plurality of resorbable film pieces (26) attached to the face of the basic structure (22). Each film piece (26) comprises a plurality of solid protrusions (28) emerging from the respective film piece (26) is a direction away from the basic structure (22).

A surgical implant (20) comprises a flexible basic structure (22) having a face and a plurality of resorbable film pieces (26) attached to the face of the basic structure (22). Each film piece (26) comprises a plurality of solid protrusions (28) emerging from the respective film piece (26) is a direction away from the basic structure (22).

The present disclosure describes a wound dressing that incorporates a biopolymer scaffold, such as a keratin-based scaffold, into collagen-based materials to increase the mechanical strength of the wound dressing. The biopolymers can increase retention times in the wound environment so that the wound dressing may serve not as a catalyst for progressing beyond the inflammatory phase of wound healing. The longer retention times also enable the wound dressing to server as a structural scaffold for tissue integration.

The present disclosure describes a wound dressing that incorporates a biopolymer scaffold, such as a keratin-based scaffold, into collagen-based materials to increase the mechanical strength of the wound dressing. The biopolymers can increase retention times in the wound environment so that the wound dressing may serve not as a catalyst for progressing beyond the inflammatory phase of wound healing. The longer retention times also enable the wound dressing to server as a structural scaffold for tissue integration.

Disclosed is an absorbent article with biocompostable properties, such as a baby diaper or adult incontinence product. Particularly, the present invention is directed to a biocompostable absorbent sanitary article including a blend of synthetic and bio-based superabsorbent polymers with a high degree of biocompostability. The sanitary article comprises, in one embodiment, at least a top layer, a back layer, and absorbent core, wherein the absorbent core includes a superabsorbent polymer, and wherein at least the superabsorbent polymer is biocompostable.

The present disclosure provides a biofragmentable sponge, comprising a three-dimensional porous scaffold formed by freeze-drying a mixture of about 5% to about 20% (w/w) of silk protein, about 5% to about 85% (w/w) of a water soluble synthetic polymer or a mixture of water soluble synthetic polymers, and about 10% to about 90% (w/w) of a polysaccharide.

The present disclosure provides a biofragmentable sponge, comprising a three-dimensional porous scaffold formed by freeze-drying a mixture of about 5% to about 20% (w/w) of silk protein, about 5% to about 85% (w/w) of a water soluble synthetic polymer or a mixture of water soluble synthetic polymers, and about 10% to about 90% (w/w) of a polysaccharide.

Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition. In addition, in some embodiments, at least a portion of the fibrinogen and/or fibrin can chemically react (e.g., the fibrinogen can polymerize to form fibrin and/or the fibrin can cross-link) during application of the compressive force. Reaction and concentration can lead to the formation of a highly-concentrated, mechanically robust patch that can be handled relatively easily and provide good structural reinforcement at a wet site, such as a bleeding wound.

Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition. In addition, in some embodiments, at least a portion of the fibrinogen and/or fibrin can chemically react (e.g., the fibrinogen can polymerize to form fibrin and/or the fibrin can cross-link) during application of the compressive force. Reaction and concentration can lead to the formation of a highly-concentrated, mechanically robust patch that can be handled relatively easily and provide good structural reinforcement at a wet site, such as a bleeding wound.

In one aspect, the present invention includes a haemostat composition that has been washed with an alkali solution to reduce the presence of endotoxins, and which is able to safely gradually and fully degrade in a human or animal body within about 30 days and so can be utilised by physicians to stem a flow of blood and promote healing both after as well as during surgical procedures.