An intervertebral fusion device includes an intervertebral stabilizing screw, and a composition is for bone remodeling. The intervertebral stabilizing screw includes a main body with an axial through-hole and a distal thread that is secured to the bone, located at a distal end of the main body. A hollow proximal secondary body can slide along the length of the main body. A travel stop for the proximal secondary body is located on an outer surface of the main body. The proximal secondary body also includes an external thread for securing to the bone, and the main body includes at least one fill hole located between the distal thread and the travel stop, for connecting an intervertebral space to the axial hole.

A bone substitute composition includes a bone substitute matrix and a conditioning solution. The bone substitute matrix includes 85% to 98% by weight of alkaline calcium phosphate powder, 1% to 10% by weight of a polymer, and 1% to 5% by weight of a crosslinker. The conditioning solution includes 90% to 97% by weight of water, 1% to 5% by weight of a phosphate, and 1% to 5% by weight of a water-soluble acidic compound.

Certain small molecule amino acid phosphate compounds such as phosphoserine and certain multivalent metal compounds such as calcium phosphate containing cements have been found to have improved properties and form an interpenetrating network in the presence of a polymer that contains either an electronegative carbonyl oxygen atom of the ester group or an electronegative nitrogen atom of the amine group as the bonding sites of the polymer surfaces to the available multivalent metal ions.

A gallium silica glass composition is described. The glass can be used in variety of biomedical applications

The present invention provides a dental material containing nanofibers and a biocompatible resin. In one embodiment, this dental material is an implant material, prosthetic material, or denture material and has mechanical strength suited to the site of use in the body as well as exceptional dimensional stability and exceptional wear resistance. Because the compressive strength can be controlled, excessive burden on the teeth when occlusal force is applied is suppressed when the dental material is used in the oral cavity. In addition, secondary caries can be suppressed because the antimicrobial properties make plaque less likely to adhere to the teeth and make the teeth less likely to be affected by bacteria. This dental material can be used without modification as a desired dental material, and can also be made into a desired dental material by molding as needed. In addition, materials produced from these nanofibers and this resin can also be used in applications other than dental materials.

The present invention relates to a soft tissue adhesive comprising an aqueous composition comprising ?-TCP and a phosphorylated amino acid. The composition has improved mechanical strength and is casily applied to the tissue.

Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

The present invention provides a bone cement composition comprising a bone matrix and a bone cement matrix formed by an acrylic polymer and an acrylic monomer, wherein the ratio of the bone matrix to the bone cement matrix is in a range from about 1:2 (g/g) to about 1:1000 (g/g). The present invention further provides a bone cement composition kit comprising a bone matrix component, a powder component, and a liquid component, respectively stored in separate containers, wherein the bone matrix component includes a bone matrix, the powder component includes an acrylic polymer, and the liquid component includes an acrylic monomer. The powder component and the liquid component are mixable to produce a bone cement matrix component. A ratio of the bone matrix component to the bone cement matrix component is in a range from about 1:2 (mL/mL) to about 1:50 (mL/mL).