Provided are synthetic bone graft substitutes that include bioactive glass and a carrier. Synthetic bone graft substitutes may include bioactive glass, glycerol and polyethylene glycol. Also provided are bone graft substitutes that include collagen and bioactive glass particles. Example bone graft substitutes may include collagen and bioactive glass particles. Other example embodiments may include Type I Bovine Collagen, an angiogenic agent, such as hyaluronic acid, and bioactive glass. Further provided are methods that include administering the present bone graft substitutes to a mammal, e.g., by surgical insertion of the bone graft substitute into the mammal, either alone or in conjunction with one or more implant devices. Further provided are kits that include the present bone grafts.

Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

Compositions useful as bone fillers or dental composites are provided which may include a sterilizing agent.

Compositions useful as bone fillers or dental composites are provided which may include a sterilizing agent.

The invention relates to a kit of parts suitable for preparing a cured biocompatible silicone polymer material including an X-ray contrast agent, the kit comprising two or more containers containing a fluid component, which componentswhen mixedform a fluid curable biocompatible polymer composition, which upon curing forms the cured biocompatible silicone polymer material, wherein a first container contains a fluid component A, which component A comprises a curable silicone (pre-)polymer and a curing agent and which component A is essentially free of curing catalyst and metallic X-ray contrast agent particles, and

a second container contains a fluid component B, which component B is a dispersion comprising metallic X-ray contrast agent particles and which is essentially free of curing agent.

The invention relates to a kit of parts suitable for preparing a cured biocompatible silicone polymer material including an X-ray contrast agent, the kit comprising two or more containers containing a fluid component, which componentswhen mixedform a fluid curable biocompatible polymer composition, which upon curing forms the cured biocompatible silicone polymer material, wherein a first container contains a fluid component A, which component A comprises a curable silicone (pre-)polymer and a curing agent and which component A is essentially free of curing catalyst and metallic X-ray contrast agent particles, and

a second container contains a fluid component B, which component B is a dispersion comprising metallic X-ray contrast agent particles and which is essentially free of curing agent.

The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.

This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas.

This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas.