Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

The present disclosure provides a method for manufacturing a porous film, including: preparing a polymer mixture solution, wherein the polymer mixture solution includes polycaprolactone and at least one hydrophobic polymer; adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture; drying the solid mixture to form a film; and washing the film with a washing fluid to remove the solid particles from the film to form the porous film, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1-10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to the solid particles is about 1:0.01-250.

A kit for preparing a paste-like bone cement, comprising a paste A and a paste B, wherein paste A contains (a1) at least one monomer for radical polymerization, (a2) at least one polymer that is soluble in (a1); and (a3)at least one polymerization initiator; and paste B contains (b1) at least one monomer for radical polymerization; (b2) at least one polymer that is soluble in (b1); and (b3) at least one polymerization accelerator; wherein at least one of the pastes A and B contains as component (a4) and/or (b4) at least one filling agent that is poorly soluble or insoluble in (a1) and/or (b1), respectively, and wherein the filling agent is a particulate inorganic filling agent possessing a BET surface of at least 40 m.sup.2/g.

The present invention provides processes for combined applications of making grooves on an implant surface, applying MgO nanoparticles with PMMA cement, restricting the cement movement by PCL nanofiber and tethering biomolecules with PCL nanofiber to enhance mechanical stability and osseointegration of PMMA cement with bone. This is achieved through enhanced osteoconductive properties, roughness, and less viable fracture originating sites at the bone-cement interface. Such combined applications of nanoparticle and nanofiber on the mechanical stability and osseointegration of cemented implant is heretofore unknown, but as provided by the present invention can solve the debonding problem of cemented implant from bone.

The present invention provides processes for combined applications of making grooves on an implant surface, applying MgO nanoparticles with PMMA cement, restricting the cement movement by PCL nanofiber and tethering biomolecules with PCL nanofiber to enhance mechanical stability and osseointegration of PMMA cement with bone. This is achieved through enhanced osteoconductive properties, roughness, and less viable fracture originating sites at the bone-cement interface. Such combined applications of nanoparticle and nanofiber on the mechanical stability and osseointegration of cemented implant is heretofore unknown, but as provided by the present invention can solve the debonding problem of cemented implant from bone.

Moisture-curable adhesive compositions, their preparation and use are disclosed herein. The moisture-curable adhesive compositions include one or more reactive polymers, such as reactive silicone polymers, one or more adhesive components, such as a silicone pressure sensitive polymer(s) (PSAs), a cross-linker and a catalyst. Typically, the reactive silicone polymer or polymers are hydroxyl terminated polydimethylsiloxanes (PDMS) having at least two hydroxyl functionalities associated with the polymer(s).

Moisture-curable adhesive compositions, their preparation and use are disclosed herein. The moisture-curable adhesive compositions include one or more reactive polymers, such as reactive silicone polymers, one or more adhesive components, such as a silicone pressure sensitive polymer(s) (PSAs), a cross-linker and a catalyst. Typically, the reactive silicone polymer or polymers are hydroxyl terminated polydimethylsiloxanes (PDMS) having at least two hydroxyl functionalities associated with the polymer(s).

An adhesive composition for bonding to bone and bone-like structures includes a polymerizable, multifunctional acidic monomer having a concentration ranging from about 5% to about 45% by weight of the adhesive composition, one or more multifunctional monomers with one or more ethylenically unsaturated groups having a concentration ranging from about 20% to about 60% by weight of the adhesive composition, an organically modified calcium phosphate salt with one or more pendant polymerizable groups having a concentration ranging from about 1% to about 50% by weight of the adhesive composition, and a polymerization initiator system. A method of forming the adhesive composition is also provided.

Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

Composition or system of a radiopaque agent including at least a first radiopaque agent in the form of a powder and at least a second radiopaque agent in the form of granules, wherein the first radiopaque agent is an equal or different material than the second radiopaque agent; method for obtaining the composition or system, filler material and kit including such radiopaque agent composition or system.