A novel glue for embolization of lymphatic leakage. An optimized lymphatic embolization agent (LEA) as described herein comprises a NAM hydrogel and tantalum at a mixture of at or about 1:3 tantalum to NAM hydrogel, wherein said LEA is radiopaque.

A novel glue for embolization of lymphatic leakage. An optimized lymphatic embolization agent (LEA) as described herein comprises a NAM hydrogel and tantalum at a mixture of at or about 1:3 tantalum to NAM hydrogel, wherein said LEA is radiopaque.

An adhesive wafer (10) for an ostomy device, the wafer comprising a skin-facing adhesive layer (40), a backing layer (30) on the non-skin-facing side of the adhesive layer, and a hole (60) for accommodating a stoma. On the central portion of the backing layer is located a release layer (110) being configured to release a neutralizer. The neutralizer is capable of neutralizing or at least minimizing the level of skin or adhesive aggressiveness of the output.

A method of making a cellulose-nanoclay hemostatic nanocomposite fiber, including the steps of preparing a homogenous cellulose solution including cellulose and a room temperature ionic liquid, preparing a nanoclay suspension including halloysite and distilled water, electrospinning the cellulose solution into a first bath including the nanoclay suspension, transferring solidified cellulose-halloysite fibers from the first bath to a second bath including ethanol and distilled water, removing the solidified cellulose-halloysite fibers from the second bath, and freeze-drying the solidified cellulose-halloysite fibers.

A bioactive adhesive for use in securing soft tissue to osseointegrated percutaneous devices includes a hydrogel precursor and a multiplicity of metal-containing mesoporous silicate nanoparticles dispersed throughout the hydrogel precursor. An antimicrobial peptide is adsorbed on surfaces of the mesoporous silicate nanoparticles, incorporated in the mesoporous silicate nanoparticles, or both. The metal-containing mesoporous silicate nanoparticles can include calcium, strontium or both and are configured to release the antimicrobial peptide over time. Adhering tissue to a metal surface includes disposing the bioactive adhesive on a metal surface, contacting a portion of tissue with the adhesive composition, and curing the adhesive composition, thereby adhering the portion of tissue to the metal surface.

A bioactive adhesive for use in securing soft tissue to osseointegrated percutaneous devices includes a hydrogel precursor and a multiplicity of metal-containing mesoporous silicate nanoparticles dispersed throughout the hydrogel precursor. An antimicrobial peptide is adsorbed on surfaces of the mesoporous silicate nanoparticles, incorporated in the mesoporous silicate nanoparticles, or both. The metal-containing mesoporous silicate nanoparticles can include calcium, strontium or both and are configured to release the antimicrobial peptide over time. Adhering tissue to a metal surface includes disposing the bioactive adhesive on a metal surface, contacting a portion of tissue with the adhesive composition, and curing the adhesive composition, thereby adhering the portion of tissue to the metal surface.

The present disclosure provides a method for manufacturing a porous film, including: preparing a polymer mixture solution, wherein the polymer mixture solution includes polycaprolactone and at least one hydrophobic polymer; adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture; drying the solid mixture to form a film; and washing the film with a washing fluid to remove the solid particles from the film to form the porous film, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1-10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to the solid particles is about 1:0.01-250.

This invention relates to anti-microbial active particles, compositions and uses thereof for inhibiting bacterial growth on surfaces or devices. This invention further discloses methods of making such anti-microbial active particles.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.